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Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

Author

Listed:
  • Haider Ghaidan

    (Skåne University Hospital
    Lund University
    Lund University
    Lund University)

  • Martin Stenlo

    (Lund University
    Lund University
    Lund University
    Skåne University Hospital)

  • Anna Niroomand

    (Lund University
    Lund University
    Lund University
    Rutgers Robert University)

  • Margareta Mittendorfer

    (Lund University
    Lund University
    Lund University)

  • Gabriel Hirdman

    (Lund University
    Lund University
    Lund University)

  • Nika Gvazava

    (Lund University
    Lund University
    Lund University)

  • Dag Edström

    (Lund University
    Lund University
    Lund University
    Skåne University Hospital)

  • Iran A. N. Silva

    (Lund University
    Lund University
    Lund University)

  • Ellen Broberg

    (Lund University
    Lund University
    Lund University
    Skåne University Hospital)

  • Oskar Hallgren

    (Lund University
    Lund University
    Lund University)

  • Franziska Olm

    (Skåne University Hospital
    Lund University
    Lund University
    Lund University)

  • Darcy E. Wagner

    (Lund University
    Lund University
    Lund University)

  • Leif Pierre

    (Skåne University Hospital
    Lund University
    Lund University
    Lund University)

  • Snejana Hyllén

    (Lund University
    Lund University
    Lund University
    Skåne University Hospital)

  • Sandra Lindstedt

    (Skåne University Hospital
    Lund University
    Lund University
    Lund University)

Abstract

Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment periods and the incidence of PGD was significantly reduced among treated animals. Overall, cytokine adsorption was able to restore lung function and reduce PGD in lung transplantation. We suggest this treatment will increase the availability of donor lungs and increase the tolerability of donor lungs in the recipient.

Suggested Citation

  • Haider Ghaidan & Martin Stenlo & Anna Niroomand & Margareta Mittendorfer & Gabriel Hirdman & Nika Gvazava & Dag Edström & Iran A. N. Silva & Ellen Broberg & Oskar Hallgren & Franziska Olm & Darcy E. W, 2022. "Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31811-5
    DOI: 10.1038/s41467-022-31811-5
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    Cited by:

    1. Ganna Petruk & Manoj Puthia & Firdaus Samsudin & Jitka Petrlova & Franziska Olm & Margareta Mittendorfer & Snejana Hyllén & Dag Edström & Ann-Charlotte Strömdahl & Carl Diehl & Simon Ekström & Björn W, 2023. "Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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