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Landscape of somatic alterations in large-scale solid tumors from an Asian population

Author

Listed:
  • Liqun Wu

    (Affiliated Hospital of Qingdao University)

  • Herui Yao

    (Sun Yat-Sen University)

  • Hui Chen

    (Shanghai OrigiMed Co., Ltd)

  • Aodi Wang

    (Shanghai OrigiMed Co., Ltd)

  • Kun Guo

    (Fudan University)

  • Wenli Gou

    (First Affiliated Hospital of Xi’an Jiao Tong University)

  • Yanfei Yu

    (Shanghai OrigiMed Co., Ltd)

  • Xiang Li

    (Shanghai OrigiMed Co., Ltd)

  • Ming Yao

    (Shanghai OrigiMed Co., Ltd)

  • Shaohua Yuan

    (Shanghai OrigiMed Co., Ltd)

  • Fei Pang

    (Shanghai OrigiMed Co., Ltd)

  • Jinwei Hu

    (Shanghai OrigiMed Co., Ltd)

  • Lijuan Chen

    (Shanghai OrigiMed Co., Ltd)

  • Wenjin Liu

    (Shanghai OrigiMed Co., Ltd)

  • Jicheng Yao

    (Shanghai OrigiMed Co., Ltd)

  • Shuirong Zhang

    (Shanghai OrigiMed Co., Ltd)

  • Xiaowei Dong

    (Shanghai OrigiMed Co., Ltd)

  • Weifeng Wang

    (Shanghai OrigiMed Co., Ltd)

  • Jing Hu

    (The First People’s Hospital of Yunnan Province)

  • Qi Ling

    (Zhejiang University)

  • Songming Ding

    (Shu Lan (Hangzhou) Hospital)

  • Yan Wei

    (The Eighth Affiliated Hospital of Guangxi Medical University)

  • Qiang Li

    (Affiliated Hospital of North Sichuan Medical University)

  • Weichun Cao

    (Central South University)

  • Shuang Wang

    (Southern Medical University)

  • Yang Di

    (Fudan University)

  • Feiling Feng

    (Shanghai Eastern Hepatobiliary Surgery Hospital)

  • Gang Zhao

    (Tianjin Medical University Cancer Institute and Hospital)

  • Jian Zhang

    (Huazhong University of Science and Technology)

  • Ling Huang

    (Huifuxi Branch of Guangdong Provincial People’s Hospital)

  • Jia Xu

    (Sun Yat-sen University)

  • Wangjun Yan

    (Fudan University)

  • Zhongsheng Tong

    (Tianjin Medical University Cancer Institute and Hospital)

  • Da Jiang

    (Fourth Hospital of Hebei Medical University)

  • Tao Ji

    (Peking University)

  • Qiao Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Ling Xu

    (Peking University First Hospital)

  • Huiying He

    (Peking University)

  • Liang Shang

    (Shandong Provincial Hospital Affiliated to Shandong University)

  • Jin Liu

    (Shandong Provincial Hospital Affiliated to Shandong University)

  • Kefeng Wang

    (Sun Yat-sen University)

  • Duoguang Wu

    (Sun Yat-sen University)

  • Jingnan Shen

    (Sun Yat-sen University)

  • Ye Liu

    (Sun Yat-sen University)

  • Ting Zhang

    (Zhejiang University)

  • Chaojie Liang

    (The First Hospital of Shanxi Medical University)

  • Yusheng Wang

    (Shanxi Provincial Cancer Hospital)

  • Yanhong Shang

    (Hebei University)

  • Jianji Guo

    (First Affiliated Hospital of Guangxi Medical University)

  • Guanbiao Liang

    (First Affiliated Hospital of Guangxi Medical University)

  • Shifeng Xu

    (Shandong Provincial Hospital Affiliated to Shandong University)

  • Junfeng Liu

    (Fourth Hospital of Hebei Medical University)

  • Kai Wang

    (Shanghai OrigiMed Co., Ltd)

  • Minghui Wang

    (Sun Yat-Sen University)

Abstract

Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tumor tissues and matched blood specimens from over 10,000 patients in China by using a 450-gene comprehensive assay, developed and implemented under international clinical regulations. We perform a comprehensive comparison of somatically altered genes, the distribution of tumor mutational burden (TMB), gene fusion patterns, and the spectrum of various somatic alterations between Chinese and American patient populations. Here, we show 64% of cancers from Chinese patients in this study have clinically actionable genomic alterations, which may affect clinical decisions related to targeted therapy or immunotherapy. These findings describe the similarities and differences between tumors from Chinese and American patients, providing valuable information for personalized medicine.

Suggested Citation

  • Liqun Wu & Herui Yao & Hui Chen & Aodi Wang & Kun Guo & Wenli Gou & Yanfei Yu & Xiang Li & Ming Yao & Shaohua Yuan & Fei Pang & Jinwei Hu & Lijuan Chen & Wenjin Liu & Jicheng Yao & Shuirong Zhang & Xi, 2022. "Landscape of somatic alterations in large-scale solid tumors from an Asian population," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31780-9
    DOI: 10.1038/s41467-022-31780-9
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    Cited by:

    1. Pengfei Yu & Can Hu & Guangyu Ding & Xiaoliang Shi & Jingli Xu & Yang Cao & Xiangliu Chen & Wei Wu & Qi Xu & Jingquan Fang & Xingmao Huang & Shaohua Yuan & Hui Chen & Zhizheng Wang & Ling Huang & Fei , 2024. "Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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