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Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

Author

Listed:
  • Hend Alhasan

    (Hokkaido University)

  • Mohamad Alaa Terkawi

    (Hokkaido University)

  • Gen Matsumae

    (Hokkaido University)

  • Taku Ebata

    (Hokkaido University)

  • Yuan Tian

    (Hokkaido University)

  • Tomohiro Shimizu

    (Hokkaido University)

  • Yoshio Nishida

    (Hokkaido University)

  • Shunichi Yokota

    (Hokkaido University)

  • Fayna Garcia-Martin

    (Hokkaido University
    University of La Rioja)

  • Mahmoud M. Abd Elwakil

    (Hokkaido University)

  • Daisuke Takahashi

    (Hokkaido University)

  • Mahmoud A. Younis

    (Hokkaido University)

  • Hideyoshi Harashima

    (Hokkaido University)

  • Ken Kadoya

    (Hokkaido University)

  • Norimasa Iwasaki

    (Hokkaido University)

Abstract

There is currently no therapy available for periprosthetic osteolysis, the most common cause of arthroplasty failure. Here, the role of AnxA1 in periprosthetic osteolysis and potential therapeutics were investigated. Reducing the expression of AnxA1 in calvarial tissue was found to be associated with increased osteolytic lesions and the osteolytic lesions induced by debris implantation were more severe in AnxA1-defecient mice than in wild-type mice. AnxA1 inhibits the differentiation of osteoclasts through suppressing NFκB signaling and promoting the PPAR-γ pathway. Administration of N-terminal-AnxA1 (Ac2-26 peptide) onto calvariae significantly reduced osteolytic lesions triggered by wear debris. These therapeutic effects were abrogated in mice that had received the PPAR-γ antagonist, suggesting that the AnxA1/PPAR-γ axis has an inhibitory role in osteolysis. The administration of Ac2–26 suppressed osteolysis induced by TNF-α and RANKL injections in mice. These findings indicate that AnxA1 is a potential therapeutic agent for the treatment of periprosthetic osteolysis.

Suggested Citation

  • Hend Alhasan & Mohamad Alaa Terkawi & Gen Matsumae & Taku Ebata & Yuan Tian & Tomohiro Shimizu & Yoshio Nishida & Shunichi Yokota & Fayna Garcia-Martin & Mahmoud M. Abd Elwakil & Daisuke Takahashi & M, 2022. "Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31646-0
    DOI: 10.1038/s41467-022-31646-0
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    References listed on IDEAS

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    1. Yongzhong Hou & France Moreau & Kris Chadee, 2012. "PPARγ is an E3 ligase that induces the degradation of NFκB/p65," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
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