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A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Author

Listed:
  • Froukje Vanweert

    (Maastricht University)

  • Michael Neinast

    (University of Pennsylvania, Philadelphia)

  • Edmundo Erazo Tapia

    (Maastricht University)

  • Tineke Weijer

    (Maastricht University
    Maastricht University Medical Center)

  • Joris Hoeks

    (Maastricht University)

  • Vera B. Schrauwen-Hinderling

    (Maastricht University
    Maastricht University Medical Center)

  • Megan C. Blair

    (University of Pennsylvania, Philadelphia)

  • Marc R. Bornstein

    (University of Pennsylvania, Philadelphia)

  • Matthijs K. C. Hesselink

    (Maastricht University)

  • Patrick Schrauwen

    (Maastricht University)

  • Zoltan Arany

    (University of Pennsylvania, Philadelphia)

  • Esther Phielix

    (Maastricht University)

Abstract

Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels improve glucose tolerance, but data in humans are lacking. Here, we used sodium phenylbutyrate (NaPB), an accelerator of BCAA catabolism, as tool to lower plasma BCAA levels in patients with T2D, and evaluate its effect on metabolic health. This trial (NetherlandsTrialRegister: NTR7426) had a randomized, placebo-controlled, double-blind cross-over design and was performed in the Maastricht University Medical Center (MUMC+), the Netherlands, between February 2019 and February 2020. Patients were eligible for the trial if they were 40–75years, BMI of 25–38 kg/m², relatively well-controlled T2D (HbA1C

Suggested Citation

  • Froukje Vanweert & Michael Neinast & Edmundo Erazo Tapia & Tineke Weijer & Joris Hoeks & Vera B. Schrauwen-Hinderling & Megan C. Blair & Marc R. Bornstein & Matthijs K. C. Hesselink & Patrick Schrauwe, 2022. "A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31249-9
    DOI: 10.1038/s41467-022-31249-9
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    Cited by:

    1. Sten M. M. Beek & Yvonne M. H. Bruls & Froukje Vanweert & Ciarán E. Fealy & Niels J. Connell & Gert Schaart & Esther Moonen-Kornips & Johanna A. Jörgensen & Frédéric M. Vaz & Ellen T. H. C. Smeets & P, 2023. "Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Hisakatsu Sone & Tae Jin Lee & Byung Rho Lee & Dan Heo & Sekyung Oh & Sang-Ho Kwon, 2023. "MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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