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Profiling Fusobacterium infection at high taxonomic resolution reveals lineage-specific correlations in colorectal cancer

Author

Listed:
  • Dexi Bi

    (Tongji University School of Medicine)

  • Yin Zhu

    (Tongji University School of Medicine)

  • Yaohui Gao

    (Tongji University School of Medicine)

  • Hao Li

    (Tongji University School of Medicine)

  • Xingchen Zhu

    (Tongji University School of Medicine)

  • Rong Wei

    (Tongji University School of Medicine)

  • Ruting Xie

    (Tongji University School of Medicine)

  • Chunmiao Cai

    (Tongji University School of Medicine)

  • Qing Wei

    (Tongji University School of Medicine)

  • Huanlong Qin

    (Tongji University School of Medicine)

Abstract

The bacterial genus Fusobacterium promotes colorectal cancer (CRC) development, but an understanding of its precise composition at the species level in the human gut and the relevant association with CRC is lacking. Herein, we devise a Fusobacterium rpoB amplicon sequencing (FrpoB-seq) method that enables the differentiation of Fusobacterium species and certain subspecies in the microbiota. By applying this method to clinical tissue and faecal samples from CRC patients, we detect 62 Fusobacterium species, including 45 that were previously undescribed. We additionally reveal that Fusobacterium species may display different lineage-dependent functions in CRC. Specifically, a lineage (designated L1) including F. nucleatum, F. hwasookii, F. periodonticum and their relatives (rather than any particular species alone) is overabundant in tumour samples and faeces from CRC patients, whereas a non-enriched lineage (designated L5) represented by F. varium and F. ulcerans in tumours has a positive association with lymphovascular invasion.

Suggested Citation

  • Dexi Bi & Yin Zhu & Yaohui Gao & Hao Li & Xingchen Zhu & Rong Wei & Ruting Xie & Chunmiao Cai & Qing Wei & Huanlong Qin, 2022. "Profiling Fusobacterium infection at high taxonomic resolution reveals lineage-specific correlations in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30957-6
    DOI: 10.1038/s41467-022-30957-6
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