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A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago

Author

Listed:
  • Theresa Catania

    (University of York)

  • Yi Li

    (University of York)

  • Thilo Winzer

    (University of York)

  • David Harvey

    (University of York)

  • Fergus Meade

    (University of York)

  • Anna Caridi

    (University of York)

  • Andrew Leech

    (University of York)

  • Tony R. Larson

    (University of York)

  • Zemin Ning

    (Wellcome Genome Campus)

  • Jiyang Chang

    (Ghent University, and VIB Centre for Plant Systems Biology)

  • Yves Peer

    (Ghent University, and VIB Centre for Plant Systems Biology
    University of Pretoria
    Nanjing Agricultural University)

  • Ian A. Graham

    (University of York)

Abstract

The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show that of the 12 Papaver species analysed those containing the STORR gene fusion also contain promorphinans/morphinans with one important exception. P. californicum encodes a functionally conserved STORR but does not produce promorphinans/morphinans. We also show that the gene fusion event occurred only once, between 16.8-24.1 million years ago before the separation of P. californicum from other Clade 2 Papaver species. The most abundant BIA in P. californicum is (R)-glaucine, a member of the aporphine subclass of BIAs, raising the possibility that STORR, once evolved, contributes to the biosynthesis of more than just the promorphinan/morphinan subclass of BIAs in the Papaveraceae.

Suggested Citation

  • Theresa Catania & Yi Li & Thilo Winzer & David Harvey & Fergus Meade & Anna Caridi & Andrew Leech & Tony R. Larson & Zemin Ning & Jiyang Chang & Yves Peer & Ian A. Graham, 2022. "A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30856-w
    DOI: 10.1038/s41467-022-30856-w
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    References listed on IDEAS

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    1. Zhenhua Liu & Jitender Cheema & Marielle Vigouroux & Lionel Hill & James Reed & Pirita Paajanen & Levi Yant & Anne Osbourn, 2020. "Formation and diversification of a paradigm biosynthetic gene cluster in plants," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Qiushi Li & Sukanya Ramasamy & Pooja Singh & Jillian M. Hagel & Sonja M. Dunemann & Xue Chen & Rongji Chen & Lisa Yu & Joseph E. Tucker & Peter J. Facchini & Sam Yeaman, 2020. "Author Correction: Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy," Nature Communications, Nature, vol. 11(1), pages 1-1, December.
    3. Xiaofei Yang & Shenghan Gao & Li Guo & Bo Wang & Yanyan Jia & Jian Zhou & Yizhuo Che & Peng Jia & Jiadong Lin & Tun Xu & Jianyong Sun & Kai Ye, 2021. "Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Qiushi Li & Sukanya Ramasamy & Pooja Singh & Jillian M. Hagel & Sonja M. Dunemann & Xue Chen & Rongji Chen & Lisa Yu & Joseph E. Tucker & Peter J. Facchini & Sam Yeaman, 2020. "Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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    1. Ren-Gang Zhang & Chaoxia Lu & Guang-Yuan Li & Jie Lv & Longxin Wang & Zhao-Xuan Wang & Zhe Chen & Dan Liu & Ye Zhao & Tian-Le Shi & Wei Zhang & Zhao-Hui Tang & Jian-Feng Mao & Yong-Peng Ma & Kai-Hua J, 2023. "Subgenome-aware analyses suggest a reticulate allopolyploidization origin in three Papaver genomes," Nature Communications, Nature, vol. 14(1), pages 1-6, December.

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