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Enyne diketones as substrate in asymmetric Nazarov cyclization for construction of chiral allene cyclopentenones

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  • Shengbiao Tang

    (Changzhou University)

  • Peng Zhang

    (Changzhou University)

  • Ying Shao

    (Changzhou University)

  • Jiangtao Sun

    (Changzhou University)

Abstract

The Nazarov cyclization is one of the most powerful tools for the stereoselective synthesis of various cyclopentenone scaffolds. Therefore, developing the new classes substrate of Nazarov reaction is an important endeavor in synthetic chemistry. Herein, we report enyne diketones, enables diastereo- and enantioselective construction of chiral allene cyclopentenones in moderate to good yields with good enantioselectivities (up to 97% ee). Importantly, it is a typical example for asymmetric synthesis of cyclopentanones with allene moiety using Nazarov cyclisation. Mechanistic studies indicate that this metal-organo relay catalysis protocol involves a rhodium-catalyzed tandem oxonium ylide formation/[2,3]-sigmatropic rearrangement/reverse benzylic acid rearrangement, followed by organo-catalyzed asymmetric Nazarov cyclization/alkyne-to-allene isomerization to give the final chiral allene cyclopentenones.

Suggested Citation

  • Shengbiao Tang & Peng Zhang & Ying Shao & Jiangtao Sun, 2022. "Enyne diketones as substrate in asymmetric Nazarov cyclization for construction of chiral allene cyclopentenones," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30846-y
    DOI: 10.1038/s41467-022-30846-y
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