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Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Author

Listed:
  • Raquel Alonso-Roman

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Antonia Last

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Mohammad H. Mirhakkak

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Jakob L. Sprague

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Lars Möller

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Peter Großmann

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Katja Graf

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute
    Dynamic42 GmbH)

  • Rena Gratz

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Selene Mogavero

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Slavena Vylkova

    (Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knoell-Institute)

  • Gianni Panagiotou

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute
    University of Hong Kong)

  • Sascha Schäuble

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

  • Bernhard Hube

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute
    Friedrich Schiller University)

  • Mark S. Gresnigt

    (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute)

Abstract

Intestinal microbiota dysbiosis can initiate overgrowth of commensal Candida species – a major predisposing factor for disseminated candidiasis. Commensal bacteria such as Lactobacillus rhamnosus can antagonize Candida albicans pathogenicity. Here, we investigate the interplay between C. albicans, L. rhamnosus, and intestinal epithelial cells by integrating transcriptional and metabolic profiling, and reverse genetics. Untargeted metabolomics and in silico modelling indicate that intestinal epithelial cells foster bacterial growth metabolically, leading to bacterial production of antivirulence compounds. In addition, bacterial growth modifies the metabolic environment, including removal of C. albicans’ favoured nutrient sources. This is accompanied by transcriptional and metabolic changes in C. albicans, including altered expression of virulence-related genes. Our results indicate that intestinal colonization with bacteria can antagonize C. albicans by reshaping the metabolic environment, forcing metabolic adaptations that reduce fungal pathogenicity.

Suggested Citation

  • Raquel Alonso-Roman & Antonia Last & Mohammad H. Mirhakkak & Jakob L. Sprague & Lars Möller & Peter Großmann & Katja Graf & Rena Gratz & Selene Mogavero & Slavena Vylkova & Gianni Panagiotou & Sascha , 2022. "Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30661-5
    DOI: 10.1038/s41467-022-30661-5
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    References listed on IDEAS

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    1. Kyla S. Ost & Teresa R. O’Meara & W. Zac Stephens & Tyson Chiaro & Haoyang Zhou & Jourdan Penman & Rickesha Bell & Jason R. Catanzaro & Deguang Song & Shakti Singh & Daniel H. Call & Elizabeth Hwang-W, 2021. "Adaptive immunity induces mutualism between commensal eukaryotes," Nature, Nature, vol. 596(7870), pages 114-118, August.
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    Cited by:

    1. Tomás Herraiz & Ana Sánchez-Arroyo & Blanca las Rivas & Rosario Muñoz, 2024. "Lactobacillus species do not produce 1-acetyl-β-carboline," Nature Communications, Nature, vol. 15(1), pages 1-4, December.
    2. Bastian Seelbinder & Zoltan Lohinai & Ruben Vazquez-Uribe & Sascha Brunke & Xiuqiang Chen & Mohammad Mirhakkak & Silvia Lopez-Escalera & Balazs Dome & Zsolt Megyesfalvi & Judit Berta & Gabriella Galff, 2023. "Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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