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Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Author

Listed:
  • Hexia Guo

    (Northwestern University
    Northwestern University)

  • Wubin Bai

    (Northwestern University
    Northwestern University
    University of North Carolina at Chapel Hill)

  • Wei Ouyang

    (Northwestern University)

  • Yihan Liu

    (University of North Carolina at Chapel Hill)

  • Changsheng Wu

    (Northwestern University)

  • Yameng Xu

    (Washington University in St. Louis)

  • Yang Weng

    (Northwestern University)

  • Hao Zang

    (Northwestern University)

  • Yiming Liu

    (Northwestern University)

  • Lauren Jacobson

    (Washington University School of Medicine)

  • Ziying Hu

    (Northwestern University)

  • Yihang Wang

    (University of North Carolina at Chapel Hill)

  • Hany M. Arafa

    (Northwestern University)

  • Quansan Yang

    (Northwestern University
    Northwestern University)

  • Di Lu

    (Northwestern University)

  • Shuo Li

    (Northwestern University)

  • Lin Zhang

    (University of North Carolina at Chapel Hill)

  • Xun Xiao

    (University of North Carolina at Chapel Hill)

  • Abraham Vázquez-Guardado

    (Northwestern University)

  • Joanna Ciatti

    (Northwestern University)

  • Elizabeth Dempsey

    (Northwestern University)

  • Nayereh Ghoreishi-Haack

    (Northwestern University)

  • Emily A. Waters

    (Northwestern University)

  • Chad R. Haney

    (Northwestern University)

  • Amanda M. Westman

    (Washington University School of Medicine)

  • Matthew R. MacEwan

    (Washington University School of Medicine)

  • Mitchell A. Pet

    (Washington University School of Medicine)

  • John A. Rogers

    (Northwestern University
    Northwestern University
    Northwestern University
    Northwestern University)

Abstract

Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

Suggested Citation

  • Hexia Guo & Wubin Bai & Wei Ouyang & Yihan Liu & Changsheng Wu & Yameng Xu & Yang Weng & Hao Zang & Yiming Liu & Lauren Jacobson & Ziying Hu & Yihang Wang & Hany M. Arafa & Quansan Yang & Di Lu & Shuo, 2022. "Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30594-z
    DOI: 10.1038/s41467-022-30594-z
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    Cited by:

    1. Long Fung Chau & Simon Lillico & Tanja Opriessnig & Rosemary Blake & Luc Tardy & Chen-Hsuin Lee & Scott Maxwell & Claire Warren & Elizabeth Thornton & Catherine L. Mclaughlin & Gerry McLachlan & Chris, 2025. "Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease," Nature Communications, Nature, vol. 16(1), pages 1-13, December.

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