IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30474-6.html
   My bibliography  Save this article

A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway

Author

Listed:
  • Bhav Harshad Parikh

    (Agency for Science, Technology and Research (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Zengping Liu

    (Agency for Science, Technology and Research (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Eye Research Institute (SERI))

  • Paul Blakeley

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Qianyu Lin

    (Agency for Science, Technology and Research (A*STAR))

  • Malay Singh

    (Agency for Science, Technology and Research (A*STAR)
    Agency for Science, Technology and Research (A*STAR))

  • Jun Yi Ong

    (Agency for Science, Technology and Research (A*STAR))

  • Kim Han Ho

    (Agency for Science, Technology and Research (A*STAR))

  • Joel Weijia Lai

    (Singapore University of Technology and Design (SUTD))

  • Hanumakumar Bogireddi

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Kim Chi Tran

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Jason Y. C. Lim

    (Agency for Science, Technology and Research (A*STAR)
    National University of Singapore)

  • Kun Xue

    (Agency for Science, Technology and Research (A*STAR))

  • Abdurrahmaan Al-Mubaarak

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Binxia Yang

    (Agency for Science, Technology and Research (A*STAR))

  • Sowmiya R

    (Agency for Science, Technology and Research (A*STAR))

  • Kakkad Regha

    (Agency for Science, Technology and Research (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Daniel Soo Lin Wong

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Queenie Shu Woon Tan

    (Agency for Science, Technology and Research (A*STAR))

  • Zhongxing Zhang

    (Agency for Science, Technology and Research (A*STAR))

  • Anand D. Jeyasekharan

    (National University of Singapore)

  • Veluchamy Amutha Barathi

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Eye Research Institute (SERI)
    Duke-NUS Medical School)

  • Weimiao Yu

    (Agency for Science, Technology and Research (A*STAR)
    Agency for Science, Technology and Research (A*STAR))

  • Kang Hao Cheong

    (Singapore University of Technology and Design (SUTD))

  • Timothy A. Blenkinsop

    (Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai)

  • Walter Hunziker

    (Agency for Science, Technology and Research (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Gopal Lingam

    (Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Eye Research Institute (SERI)
    National University Hospital)

  • Xian Jun Loh

    (Agency for Science, Technology and Research (A*STAR)
    National University of Singapore)

  • Xinyi Su

    (Agency for Science, Technology and Research (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore
    Singapore Eye Research Institute (SERI)
    National University Hospital)

Abstract

One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2–related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention.

Suggested Citation

  • Bhav Harshad Parikh & Zengping Liu & Paul Blakeley & Qianyu Lin & Malay Singh & Jun Yi Ong & Kim Han Ho & Joel Weijia Lai & Hanumakumar Bogireddi & Kim Chi Tran & Jason Y. C. Lim & Kun Xue & Abdurrahm, 2022. "A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30474-6
    DOI: 10.1038/s41467-022-30474-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30474-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30474-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30474-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.