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The planarian wound epidermis gene equinox is required for blastema formation in regeneration

Author

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  • M. Lucila Scimone

    (Massachusetts Institute of Technology
    Whitehead Institute for Biomedical Research)

  • Jennifer K. Cloutier

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology
    Harvard Medical School)

  • Chloe L. Maybrun

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

  • Peter W. Reddien

    (Massachusetts Institute of Technology
    Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

Abstract

Regeneration often involves the formation of a blastema, an outgrowth or regenerative bud formed at the plane of injury where missing tissues are produced. The mechanisms that trigger blastema formation are therefore fundamental for regeneration. Here, we identify a gene, which we named equinox, that is expressed within hours of injury in the planarian wound epidermis. equinox encodes a predicted secreted protein that is conserved in many animal phyla. Following equinox inhibition, amputated planarians fail to maintain wound-induced gene expression and to subsequently undergo blastema outgrowth. Associated with these defects is an inability to reestablish lost positional information needed for missing tissue specification. Our findings link the planarian wound epidermis, through equinox, to regeneration of positional information and blastema formation, indicating a broad regulatory role of the wound epidermis in diverse regenerative contexts.

Suggested Citation

  • M. Lucila Scimone & Jennifer K. Cloutier & Chloe L. Maybrun & Peter W. Reddien, 2022. "The planarian wound epidermis gene equinox is required for blastema formation in regeneration," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30412-6
    DOI: 10.1038/s41467-022-30412-6
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    References listed on IDEAS

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    1. M. Lucila Scimone & Lauren E. Cote & Peter W. Reddien, 2017. "Orthogonal muscle fibres have different instructive roles in planarian regeneration," Nature, Nature, vol. 551(7682), pages 623-628, November.
    2. Suthira Owlarn & Felix Klenner & David Schmidt & Franziska Rabert & Antonio Tomasso & Hanna Reuter & Medhanie A. Mulaw & Sören Moritz & Luca Gentile & Gilbert Weidinger & Kerstin Bartscherer, 2017. "Generic wound signals initiate regeneration in missing-tissue contexts," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
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    Cited by:

    1. Eudald Pascual-Carreras & Marta Marín-Barba & Sergio Castillo-Lara & Pablo Coronel-Córdoba & Marta Silvia Magri & Grant N. Wheeler & Jose Luis Gómez-Skarmeta & Josep F. Abril & Emili Saló & Teresa Ade, 2023. "Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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