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POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis

Author

Listed:
  • Yong Xue

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences)

  • Jiang-Guo Meng

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Peng-Fei Jia

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences)

  • Zheng-Rong Zhang

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hong-Ju Li

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wei-Cai Yang

    (State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Protein sorting in the secretory pathway is essential for cellular compartmentalization and homeostasis in eukaryotic cells. The endoplasmic reticulum (ER) is the biosynthetic and folding factory of secretory cargo proteins. The cargo transport from the ER to the Golgi is highly selective, but the molecular mechanism for the sorting specificity is unclear. Here, we report that three ER membrane localized proteins, SUN3, SUN4 and SUN5, regulate ER sorting of leucine-rich repeat receptor kinases (LRR-RKs) to the plasma membrane. The triple mutant sun3/4/5 displays mis-sorting of these cargo proteins to acidic compartments and therefore impairs the growth of pollen tubes and the whole plant. Furthermore, the extracellular LRR domain of LRR-RKs is responsible for the correct sorting. Together, this study reports a mechanism that is important for the sorting of cell surface receptors.

Suggested Citation

  • Yong Xue & Jiang-Guo Meng & Peng-Fei Jia & Zheng-Rong Zhang & Hong-Ju Li & Wei-Cai Yang, 2022. "POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30179-w
    DOI: 10.1038/s41467-022-30179-w
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    References listed on IDEAS

    as
    1. Tong Wang & Liang Liang & Yong Xue & Peng-Fei Jia & Wei Chen & Meng-Xia Zhang & Ying-Chun Wang & Hong-Ju Li & Wei-Cai Yang, 2016. "A receptor heteromer mediates the male perception of female attractants in plants," Nature, Nature, vol. 531(7593), pages 241-244, March.
    2. Tong Wang & Liang Liang & Yong Xue & Peng-Fei Jia & Wei Chen & Meng-Xia Zhang & Ying-Chun Wang & Hong-Ju Li & Wei-Cai Yang, 2016. "Correction: Corrigendum: A receptor heteromer mediates the male perception of female attractants in plants," Nature, Nature, vol. 536(7616), pages 360-360, August.
    3. Hidenori Takeuchi & Tetsuya Higashiyama, 2016. "Tip-localized receptors control pollen tube growth and LURE sensing in Arabidopsis," Nature, Nature, vol. 531(7593), pages 245-248, March.
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