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Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

Author

Listed:
  • Yun Zhang

    (Tongji University School of Medicine)

  • Shuaijun Li

    (Tongji University School of Medicine)

  • Peisheng Jin

    (Affiliated Hospital of Xuzhou Medical University)

  • Ting Shang

    (Capital Medical University)

  • Ruizhu Sun

    (Tongji University School of Medicine)

  • Laiya Lu

    (Tongji University School of Medicine)

  • Kaijin Guo

    (Affiliated Hospital of Xuzhou Medical University)

  • Jiping Liu

    (Tongji University School of Medicine)

  • Yongjuan Tong

    (Capital Medical University)

  • Junbang Wang

    (Tongji University School of Medicine)

  • Sanhong Liu

    (ShanghaiTech University)

  • Chen Wang

    (ShanghaiTech University)

  • Yubin Kang

    (Capital Medical University)

  • Wenmin Zhu

    (Tongji University School of Medicine)

  • Qian Wang

    (Tongji University School of Medicine)

  • Xiaoren Zhang

    (Affiliated Cancer Hospital & Institute of Guangzhou Medical University)

  • Feng Yin

    (Tongji University School of Medicine)

  • Yi Eve Sun

    (Tongji University School of Medicine)

  • Lei Cui

    (Tongji University School of Medicine
    Tongji University School of Medicine
    Capital Medical University)

Abstract

Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) “difficult-to-treat”. Cartilage destruction is central to OA patho-etiology and is mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributes to OA progression. Supplementation of exogenous miR-17 or its endogenous induction by growth differentiation factor 5, effectively prevented OA by simultaneously targeting pathological catabolic factors including matrix metallopeptidase-3/13 (MMP3/13), aggrecanase-2 (ADAMTS5), and nitric oxide synthase-2 (NOS2). Single-cell RNA sequencing of hyaline cartilage revealed two distinct superficial chondrocyte populations (C1/C2). C1 expressed physiological catabolic factors including MMP2, and C2 carries synovial features, together with C3 in the middle zone. MiR-17 is highly expressed in both superficial and middle chondrocytes under physiological conditions, and maintains the physiological catabolic and anabolic balance potentially by restricting HIF-1α signaling. Together, this study identified dual functions of miR-17 in maintaining cartilage homeostasis and prevention of OA.

Suggested Citation

  • Yun Zhang & Shuaijun Li & Peisheng Jin & Ting Shang & Ruizhu Sun & Laiya Lu & Kaijin Guo & Jiping Liu & Yongjuan Tong & Junbang Wang & Sanhong Liu & Chen Wang & Yubin Kang & Wenmin Zhu & Qian Wang & X, 2022. "Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30119-8
    DOI: 10.1038/s41467-022-30119-8
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    References listed on IDEAS

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    1. Chuanyue Wu & Hongli Jiao & Yumei Lai & Wei Zheng & Ka Chen & Hong Qu & Weimin Deng & Pingping Song & Ke Zhu & Huiling Cao & Deborah L. Galson & Jie Fan & Hee-Jeong Im & Yujie Liu & Ju Chen & Di Chen , 2015. "Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
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