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Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Author

Listed:
  • Raffaele Marfella

    (Università degli Studi della Campania “Luigi Vanvitelli”
    Mediterranea Cardiocentro)

  • Celestino Sardu

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Nunzia D’Onofrio

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Francesco Prattichizzo

    (IRCCS MultiMedica)

  • Lucia Scisciola

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Vincenzo Messina

    (Sant’Anna Hospital)

  • Rosalba La Grotta

    (IRCCS MultiMedica)

  • Maria Luisa Balestrieri

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Paolo Maggi

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Claudio Napoli

    (Università degli Studi della Campania “Luigi Vanvitelli”)

  • Antonio Ceriello

    (IRCCS MultiMedica)

  • Giuseppe Paolisso

    (Università degli Studi della Campania “Luigi Vanvitelli”
    Mediterranea Cardiocentro)

Abstract

Patients with type 2 diabetes (T2D) are characterized by blunted immune responses, which are affected by glycaemic control. Whether glycaemic control influences the response to COVID-19 vaccines and the incidence of SARS-CoV-2 breakthrough infections is unknown. Here we show that poor glycaemic control, assessed as mean HbA1c in the post-vaccination period, is associated with lower immune responses and an increased incidence of SARS-CoV-2 breakthrough infections in T2D patients vaccinated with mRNA-BNT162b2. We report data from a prospective observational study enroling healthcare and educator workers with T2D receiving the mRNA-BNT162b2 vaccine in Campania (Italy) and followed for one year (5 visits, follow-up 346 ± 49 days) after one full vaccination cycle. Considering the 494 subjects completing the study, patients with good glycaemic control (HbA1c one-year mean

Suggested Citation

  • Raffaele Marfella & Celestino Sardu & Nunzia D’Onofrio & Francesco Prattichizzo & Lucia Scisciola & Vincenzo Messina & Rosalba La Grotta & Maria Luisa Balestrieri & Paolo Maggi & Claudio Napoli & Anto, 2022. "Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30068-2
    DOI: 10.1038/s41467-022-30068-2
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