IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30004-4.html
   My bibliography  Save this article

ERK1/2 is an ancestral organising signal in spiral cleavage

Author

Listed:
  • Océane Seudre

    (School of Biological and Behavioural Sciences. Queen Mary University of London)

  • Allan M. Carrillo-Baltodano

    (School of Biological and Behavioural Sciences. Queen Mary University of London)

  • Yan Liang

    (School of Biological and Behavioural Sciences. Queen Mary University of London)

  • José M. Martín-Durán

    (School of Biological and Behavioural Sciences. Queen Mary University of London)

Abstract

Animal development is classified as conditional or autonomous based on whether cell fates are specified through inductive signals or maternal determinants, respectively. Yet how these two major developmental modes evolved remains unclear. During spiral cleavage—a stereotypic embryogenesis ancestral to 15 invertebrate groups, including molluscs and annelids—most lineages specify cell fates conditionally, while some define the primary axial fates autonomously. To identify the mechanisms driving this change, we study Owenia fusiformis, an early-branching, conditional annelid. In Owenia, ERK1/2-mediated FGF receptor signalling specifies the endomesodermal progenitor. This cell likely acts as an organiser, inducing mesodermal and posterodorsal fates in neighbouring cells and repressing anteriorising signals. The organising role of ERK1/2 in Owenia is shared with molluscs, but not with autonomous annelids. Together, these findings suggest that conditional specification of an ERK1/2+ embryonic organiser is ancestral in spiral cleavage and was repeatedly lost in annelid lineages with autonomous development.

Suggested Citation

  • Océane Seudre & Allan M. Carrillo-Baltodano & Yan Liang & José M. Martín-Durán, 2022. "ERK1/2 is an ancestral organising signal in spiral cleavage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30004-4
    DOI: 10.1038/s41467-022-30004-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30004-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30004-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Giacomo Moggioli & Balig Panossian & Yanan Sun & Daniel Thiel & Francisco M. Martín-Zamora & Martin Tran & Alexander M. Clifford & Shana K. Goffredi & Nadezhda Rimskaya-Korsakova & Gáspár Jékely & Mar, 2023. "Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30004-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.