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Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C

Author

Listed:
  • Conor McCafferty

    (Haematology Research, Murdoch Children’s Research Institute
    University of Melbourne)

  • Tengyi Cai

    (Haematology Research, Murdoch Children’s Research Institute)

  • Delphine Borgel

    (Necker Hospital, AP-HP)

  • Dominique Lasne

    (Necker Hospital, AP-HP)

  • Sylvain Renolleau

    (Necker Hospital AP-HP)

  • Meryl Vedrenne-Cloquet

    (Necker Hospital AP-HP)

  • Damien Bonnet

    (M3C-Necker, Congenital and Pediatric Cardiology, Necker Hospital, AP-HP)

  • Jemma Wu

    (Australian Proteome Analysis Facility)

  • Thiri Zaw

    (Australian Proteome Analysis Facility)

  • Atul Bhatnagar

    (Australian Proteome Analysis Facility)

  • Xiaomin Song

    (Australian Proteome Analysis Facility)

  • Suelyn Van Den Helm

    (Haematology Research, Murdoch Children’s Research Institute)

  • Natasha Letunica

    (Haematology Research, Murdoch Children’s Research Institute)

  • Chantal Attard

    (Haematology Research, Murdoch Children’s Research Institute
    University of Melbourne)

  • Vasiliki Karlaftis

    (Haematology Research, Murdoch Children’s Research Institute)

  • Slavica Praporski

    (Haematology Research, Murdoch Children’s Research Institute)

  • Vera Ignjatovic

    (Haematology Research, Murdoch Children’s Research Institute
    University of Melbourne)

  • Paul Monagle

    (Haematology Research, Murdoch Children’s Research Institute
    University of Melbourne
    Royal Children’s Hospital
    Sydney Children’s Hospital)

Abstract

COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children.

Suggested Citation

  • Conor McCafferty & Tengyi Cai & Delphine Borgel & Dominique Lasne & Sylvain Renolleau & Meryl Vedrenne-Cloquet & Damien Bonnet & Jemma Wu & Thiri Zaw & Atul Bhatnagar & Xiaomin Song & Suelyn Van Den H, 2022. "Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29951-9
    DOI: 10.1038/s41467-022-29951-9
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