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Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection

Author

Listed:
  • Jessica S. Little

    (Division of Infectious Diseases, Brigham and Women’s Hospital
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Rebekah M. Dedrick

    (University of Pittsburgh)

  • Krista G. Freeman

    (University of Pittsburgh)

  • Madison Cristinziano

    (University of Pittsburgh)

  • Bailey E. Smith

    (University of Pittsburgh)

  • Constance A. Benson

    (University of California San Diego)

  • Tulip A. Jhaveri

    (Division of Medical Microbiology, Brigham and Women’s Hospital
    University of Mississippi Medical Center)

  • Lindsey R. Baden

    (Division of Infectious Diseases, Brigham and Women’s Hospital
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Daniel A. Solomon

    (Division of Infectious Diseases, Brigham and Women’s Hospital
    Harvard Medical School)

  • Graham F. Hatfull

    (University of Pittsburgh)

Abstract

Mycobacterium chelonae is a rare cause of chronic disseminated cutaneous infections in immunocompromised patients. Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant toxicities and further antimicrobial resistance. We report a case of refractory cutaneous disseminated M. chelonae infection in a patient with seronegative arthritis on immunotherapy with tofacitinib that was treated with combination antimicrobial, surgical, and single bacteriophage therapy with excellent clinical response. The patient developed neutralizing antibodies against the bacteriophage but continues to have stable improvement of disease with negative biopsies and no evidence of bacterial resistance to the phage.

Suggested Citation

  • Jessica S. Little & Rebekah M. Dedrick & Krista G. Freeman & Madison Cristinziano & Bailey E. Smith & Constance A. Benson & Tulip A. Jhaveri & Lindsey R. Baden & Daniel A. Solomon & Graham F. Hatfull, 2022. "Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29689-4
    DOI: 10.1038/s41467-022-29689-4
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    Cited by:

    1. Madison Cristinziano & Elena Shashkina & Liang Chen & Jaime Xiao & Melissa B. Miller & Christina Doligalski & Raymond Coakley & Leonard Jason Lobo & Brent Footer & Luther Bartelt & Lawrence Abad & Dan, 2024. "Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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