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Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Author

Listed:
  • Livia V. Patrono

    (Robert Koch Institute
    Robert Koch Institute)

  • Bram Vrancken

    (KU Leuven)

  • Matthias Budt

    (Robert Koch Institute)

  • Ariane Düx

    (Robert Koch Institute
    Robert Koch Institute)

  • Sebastian Lequime

    (University of Groningen)

  • Sengül Boral

    (Institute for Pathology)

  • M. Thomas P. Gilbert

    (University of Copenhagen
    NTNU)

  • Jan F. Gogarten

    (Robert Koch Institute
    Robert Koch Institute)

  • Luisa Hoffmann

    (Robert Koch Institute)

  • David Horst

    (Institute for Pathology)

  • Kevin Merkel

    (Robert Koch Institute
    Robert Koch Institute)

  • David Morens

    (National Institute of Allergy and Infectious Diseases)

  • Baptiste Prepoint

    (Robert Koch Institute
    PSL Université Paris)

  • Jasmin Schlotterbeck

    (Robert Koch Institute)

  • Verena J. Schuenemann

    (University of Zurich)

  • Marc A. Suchard

    (University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles)

  • Jeffery K. Taubenberger

    (National Institute of Allergy and Infectious Diseases)

  • Luisa Tenkhoff

    (Robert Koch Institute)

  • Christian Urban

    (University of Zurich)

  • Navena Widulin

    (Berlin Museum of Medical History)

  • Eduard Winter

    (Natural History Museum of Vienna)

  • Michael Worobey

    (University of Arizona)

  • Thomas Schnalke

    (Berlin Museum of Medical History)

  • Thorsten Wolff

    (Robert Koch Institute)

  • Philippe Lemey

    (KU Leuven)

  • Sébastien Calvignac-Spencer

    (Robert Koch Institute
    Robert Koch Institute)

Abstract

The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

Suggested Citation

  • Livia V. Patrono & Bram Vrancken & Matthias Budt & Ariane Düx & Sebastian Lequime & Sengül Boral & M. Thomas P. Gilbert & Jan F. Gogarten & Luisa Hoffmann & David Horst & Kevin Merkel & David Morens &, 2022. "Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29614-9
    DOI: 10.1038/s41467-022-29614-9
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    References listed on IDEAS

    as
    1. Michael Worobey & Guan-Zhu Han & Andrew Rambaut, 2014. "A synchronized global sweep of the internal genes of modern avian influenza virus," Nature, Nature, vol. 508(7495), pages 254-257, April.
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    Cited by:

    1. Bernhard, Marco & Leuch, Corina & Kordi, Maryam & Gruebner, Oliver & Matthes, Katarina L. & Floris, Joël & Staub, Kaspar, 2023. "From pandemic to endemic: Spatial-temporal patterns of influenza-like illness incidence in a Swiss canton, 1918–1924," Economics & Human Biology, Elsevier, vol. 50(C).

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