IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29578-w.html
   My bibliography  Save this article

Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

Author

Listed:
  • Ofra Amir

    (Technion—Israel Institute of Technology)

  • Yair Goldberg

    (Technion—Israel Institute of Technology)

  • Micha Mandel

    (The Hebrew University of Jerusalem)

  • Yinon M. Bar-On

    (Weizmann Institute of Science)

  • Omri Bodenheimer

    (Israel Ministry of Health)

  • Nachman Ash

    (Israel Ministry of Health)

  • Sharon Alroy-Preis

    (Israel Ministry of Health)

  • Amit Huppert

    (The Bio-statistical and Bio-mathematical Unit, The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center
    Tel Aviv University)

  • Ron Milo

    (Weizmann Institute of Science)

Abstract

Israel began administering a BNT162b2 booster dose to restore protection following the waning of the 2-dose vaccine. Biological studies have shown that a “fresh” booster dose leads to increased antibody levels compared to a fresh 2-dose vaccine, which may suggest increased effectiveness. To compare the real-world effectiveness of a fresh (up to 60 days) booster dose with that of a fresh 2-dose vaccine, we took advantage of a quasi-experimental study that compares populations that were eligible to receive the vaccine at different times due to age-dependent policies. Specifically, we compared the confirmed infection rates in adolescents aged 12–14 (215,653 individuals) who received the 2-dose vaccine and in adolescents aged 16–18 (103,454 individuals) who received the booster dose. Our analysis shows that the confirmed infection rate was lower by a factor of 3.7 (95% CI: 2.7 to 5.2) in the booster group.

Suggested Citation

  • Ofra Amir & Yair Goldberg & Micha Mandel & Yinon M. Bar-On & Omri Bodenheimer & Nachman Ash & Sharon Alroy-Preis & Amit Huppert & Ron Milo, 2022. "Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29578-w
    DOI: 10.1038/s41467-022-29578-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29578-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-29578-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29578-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.