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Non-metallic T2-MRI agents based on conjugated polymers

Author

Listed:
  • Qinrui Lin

    (Fudan University
    Fudan University)

  • Yuhong Yang

    (Fudan University)

  • Zhengzhong Shao

    (Fudan University
    Fudan University
    Fudan University
    Nanjing Normal University)

Abstract

Developing non-metallic contrast agents of clinically applied magnetic resonance imaging (MRI) is an alternative strategy to reduce the toxicity of heavy metal elements in current MRI agents. These non-metallic MRI agents usually generate contrasts by unpaired electrons, which are prone to be deactivated by in vivo radical scavenging pathways. Since the unpaired electrons in conjugated polymers exhibit satisfying stability for in vivo imaging, developing conjugated polymers based MRI agents may solve the in vivo stability problem of current non-metallic agents. However, MRI-active properties have not been reported in existing conjugated polymers yet. Herein we report on MRI-active conjugated polymer nanoparticles based on polypyrrole (PPy), which can be used for in vivo imaging. Our method not only introduce a kind of non-metallic MRI agents but extends the applications of conjugated polymers from optical imagings to MRI.

Suggested Citation

  • Qinrui Lin & Yuhong Yang & Zhengzhong Shao, 2022. "Non-metallic T2-MRI agents based on conjugated polymers," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29569-x
    DOI: 10.1038/s41467-022-29569-x
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