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DNA methylation in newborns conceived by assisted reproductive technology

Author

Listed:
  • Siri E. Håberg

    (Norwegian Institute of Public Health)

  • Christian M. Page

    (Norwegian Institute of Public Health
    University of Oslo)

  • Yunsung Lee

    (Norwegian Institute of Public Health)

  • Haakon E. Nustad

    (Norwegian Institute of Public Health
    Deepinsight, Karl Johans gate 8)

  • Maria C. Magnus

    (Norwegian Institute of Public Health
    MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove
    Bristol Medical School, Oakfield House, Oakfield Grove)

  • Kristine L. Haftorn

    (Norwegian Institute of Public Health)

  • Ellen Ø. Carlsen

    (Norwegian Institute of Public Health)

  • William R. P. Denault

    (Norwegian Institute of Public Health
    University of Chicago)

  • Jon Bohlin

    (Norwegian Institute of Public Health
    Norwegian Institute of Public Health)

  • Astanand Jugessur

    (Norwegian Institute of Public Health
    University of Bergen)

  • Per Magnus

    (Norwegian Institute of Public Health)

  • Håkon K. Gjessing

    (Norwegian Institute of Public Health
    University of Bergen)

  • Robert Lyle

    (Norwegian Institute of Public Health
    Oslo University Hospital, OUS HF)

Abstract

Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo implantation. However, it is unknown to what extent ART procedures alter the fetal epigenome. Underlying parental characteristics and subfertility may also play a role. Here we identify differences in cord blood DNA methylation, measured using the Illumina EPIC platform, between 962 ART conceived and 983 naturally conceived singleton newborns. We show that ART conceived newborns display widespread differences in DNA methylation, and overall less methylation across the genome. There were 607 genome-wide differentially methylated CpGs. We find differences in 176 known genes, including genes related to growth, neurodevelopment, and other health outcomes that have been associated with ART. Both fresh and frozen embryo transfer show DNA methylation differences. Associations persist after controlling for parents’ DNA methylation, and are not explained by parental subfertility.

Suggested Citation

  • Siri E. Håberg & Christian M. Page & Yunsung Lee & Haakon E. Nustad & Maria C. Magnus & Kristine L. Haftorn & Ellen Ø. Carlsen & William R. P. Denault & Jon Bohlin & Astanand Jugessur & Per Magnus & H, 2022. "DNA methylation in newborns conceived by assisted reproductive technology," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29540-w
    DOI: 10.1038/s41467-022-29540-w
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