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Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke

Author

Listed:
  • Byeongtaek Oh

    (Stanford University School of Medicine)

  • Sruthi Santhanam

    (Stanford University School of Medicine)

  • Matine Azadian

    (Stanford University School of Medicine)

  • Vishal Swaminathan

    (Stanford University School of Medicine)

  • Alex G. Lee

    (University of California)

  • Kelly W. McConnell

    (Stanford University School of Medicine)

  • Alexa Levinson

    (Stanford University School of Medicine)

  • Shang Song

    (Stanford University School of Medicine)

  • Jainith J. Patel

    (Stanford University School of Medicine)

  • Emily E. Gardner

    (Stanford University School of Medicine)

  • Paul M. George

    (Stanford University School of Medicine)

Abstract

Stroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are a promising stroke therapeutic, but creating ideal conditions for treatment is essential. Here we developed a conductive polymer system for stem cell delivery and electrical modulation in animals. Using this system, electrical modulation of human stem cell transplants improve functional stroke recovery in rodents. Increased endogenous stem cell production corresponds with improved function. Transcriptome analysis identified stanniocalcin 2 (STC2) as one of the genes most significantly upregulated by electrical stimulation. Lentiviral upregulation and downregulation of STC2 in the transplanted stem cells demonstrate that this glycoprotein is an essential mediator in the functional improvements seen with electrical modulation. Moreover, intraventricular administration of recombinant STC2 post-stroke confers functional benefits. In summation, our conductive polymer system enables electrical modulation of stem cells as a potential method to improve recovery and identify important therapeutic targets.

Suggested Citation

  • Byeongtaek Oh & Sruthi Santhanam & Matine Azadian & Vishal Swaminathan & Alex G. Lee & Kelly W. McConnell & Alexa Levinson & Shang Song & Jainith J. Patel & Emily E. Gardner & Paul M. George, 2022. "Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29017-w
    DOI: 10.1038/s41467-022-29017-w
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    Cited by:

    1. Nan Hu & Jian-Xin Shi & Chong Chen & Hai-Huan Xu & Zhe-Han Chang & Peng-Fei Hu & Di Guo & Xiao-Wang Zhang & Wen-Wei Shao & Xiu Fan & Jia-Chen Zuo & Dong Ming & Xiao-Hong Li, 2024. "Constructing organoid-brain-computer interfaces for neurofunctional repair after brain injury," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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