Author
Listed:
- Giselle Cheung
(Université PSL
Institute of Science and Technology Austria)
- Danijela Bataveljic
(Université PSL
University of Belgrade)
- Josien Visser
(Université PSL
Pierre and Marie Curie University)
- Naresh Kumar
(Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM)
- Julien Moulard
(Université PSL
Pierre and Marie Curie University)
- Glenn Dallérac
(Université PSL
Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay)
- Daria Mozheiko
(Université PSL
Pierre and Marie Curie University)
- Astrid Rollenhagen
(Research Center Jülich
Rheinisch-Westfaelische Technische Hochschule Aachen University)
- Pascal Ezan
(Université PSL)
- Cédric Mongin
(Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM)
- Oana Chever
(Université PSL
Normandy University, UNIROUEN, INSERM, DC2N)
- Alexis-Pierre Bemelmans
(Université Paris-Sud, Neurodegenerative Diseases Laboratory)
- Joachim Lübke
(Research Center Jülich
Rheinisch-Westfaelische Technische Hochschule Aachen University
Jülich-Aachen Research Alliance Translational Brain Medicine)
- Isabelle Leray
(Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM)
- Nathalie Rouach
(Université PSL)
Abstract
Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process is thought to rely on the glutamate-glutamine cycle between neurons and astrocytes. However the presence of an astroglial glutamine supply, as well as its functional relevance in vivo in the healthy brain remain controversial, partly due to a lack of tools that can directly examine glutamine transfer. Here, we generated a fluorescent probe that tracks glutamine in live cells, which provides direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions. This mobilization is mediated by connexin43, an astroglial protein with both gap-junction and hemichannel functions, and is essential for synaptic transmission and object recognition memory. Our findings uncover an indispensable recruitment of astroglial glutamine in physiological synaptic activity and memory via an unconventional pathway, thus providing an astrocyte basis for cognitive processes.
Suggested Citation
Giselle Cheung & Danijela Bataveljic & Josien Visser & Naresh Kumar & Julien Moulard & Glenn Dallérac & Daria Mozheiko & Astrid Rollenhagen & Pascal Ezan & Cédric Mongin & Oana Chever & Alexis-Pierre , 2022.
"Physiological synaptic activity and recognition memory require astroglial glutamine,"
Nature Communications, Nature, vol. 13(1), pages 1-17, December.
Handle:
RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28331-7
DOI: 10.1038/s41467-022-28331-7
Download full text from publisher
Citations
Citations are extracted by the
CitEc Project, subscribe to its
RSS feed for this item.
Cited by:
- Woo-Hyun Cho & Kyungchul Noh & Byung Hun Lee & Ellane Barcelon & Sang Beom Jun & Hye Yoon Park & Sung Joong Lee, 2022.
"Hippocampal astrocytes modulate anxiety-like behavior,"
Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Moises Freitas-Andrade & Cesar H. Comin & Peter Dyken & Julie Ouellette & Joanna Raman-Nair & Nicole Blakeley & Qing Yan Liu & Sonia Leclerc & Youlian Pan & Ziying Liu & Micaël Carrier & Karan Thakur , 2023.
"Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation,"
Nature Communications, Nature, vol. 14(1), pages 1-20, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28331-7. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.