IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28150-w.html
   My bibliography  Save this article

Activation of the plant mevalonate pathway by extracellular ATP

Author

Listed:
  • Sung-Hwan Cho

    (University of Missouri)

  • Katalin Tóth

    (University of Missouri
    Inari Agriculture, NV, Industriepark Zwijnaarde 7A)

  • Daewon Kim

    (University of Missouri)

  • Phuc H. Vo

    (University of Missouri
    International University, Vietnam National University)

  • Chung-Ho Lin

    (University of Missouri)

  • Pubudu P. Handakumbura

    (Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory)

  • Albert Rivas Ubach

    (Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory)

  • Sterling Evans

    (University of Missouri)

  • Ljiljana Paša-Tolić

    (Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory)

  • Gary Stacey

    (University of Missouri)

Abstract

The mevalonate pathway plays a critical role in multiple cellular processes in both animals and plants. In plants, the products of this pathway impact growth and development, as well as the response to environmental stress. A forward genetic screen of Arabidopsis thaliana using Ca2+-imaging identified mevalonate kinase (MVK) as a critical component of plant purinergic signaling. MVK interacts directly with the plant extracellular ATP (eATP) receptor P2K1 and is phosphorylated by P2K1 in response to eATP. Mutation of P2K1-mediated phosphorylation sites in MVK eliminates the ATP-induced cytoplasmic calcium response, MVK enzymatic activity, and suppresses pathogen defense. The data demonstrate that the plasma membrane associated P2K1 directly impacts plant cellular metabolism by phosphorylation of MVK, a key enzyme in the mevalonate pathway. The results underline the importance of purinergic signaling in plants and the ability of eATP to influence the activity of a key metabolite pathway with global effects on plant metabolism.

Suggested Citation

  • Sung-Hwan Cho & Katalin Tóth & Daewon Kim & Phuc H. Vo & Chung-Ho Lin & Pubudu P. Handakumbura & Albert Rivas Ubach & Sterling Evans & Ljiljana Paša-Tolić & Gary Stacey, 2022. "Activation of the plant mevalonate pathway by extracellular ATP," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28150-w
    DOI: 10.1038/s41467-022-28150-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28150-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28150-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28150-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.