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Ion currents through Kir potassium channels are gated by anionic lipids

Author

Listed:
  • Ruitao Jin

    (La Trobe University)

  • Sitong He

    (La Trobe University)

  • Katrina A. Black

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Oliver B. Clarke

    (Columbia University)

  • Di Wu

    (University of Oxford
    The Kavli Institute for Nanoscience Discovery)

  • Jani R. Bolla

    (The Kavli Institute for Nanoscience Discovery
    University of Oxford)

  • Paul Johnson

    (University of Newcastle and Hunter Medical Research Institute)

  • Agalya Periasamy

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Ahmad Wardak

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Peter Czabotar

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Peter M. Colman

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Carol V. Robinson

    (University of Oxford
    The Kavli Institute for Nanoscience Discovery)

  • Derek Laver

    (University of Newcastle and Hunter Medical Research Institute)

  • Brian J. Smith

    (La Trobe University)

  • Jacqueline M. Gulbis

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

Abstract

Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our understanding of how these channels are gated. Here we present evidence that anionic lipids act as interactive response elements sufficient to gate potassium conduction. We demonstrate the limiting barrier to K+ permeation lies within the ion conduction pathway and show that this gate is operated by the fatty acyl tails of lipids that infiltrate the conduction pathway via fenestrations in the walls of the pore. Acyl tails occupying a surface groove extending from the cytosolic interface to the conduction pathway provide a potential means of relaying cellular signals, mediated by anionic lipid head groups bound at the canonical lipid binding site, to the internal gate.

Suggested Citation

  • Ruitao Jin & Sitong He & Katrina A. Black & Oliver B. Clarke & Di Wu & Jani R. Bolla & Paul Johnson & Agalya Periasamy & Ahmad Wardak & Peter Czabotar & Peter M. Colman & Carol V. Robinson & Derek Lav, 2022. "Ion currents through Kir potassium channels are gated by anionic lipids," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28148-4
    DOI: 10.1038/s41467-022-28148-4
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    Cited by:

    1. Ruo-Xu Gu & Bert L. Groot, 2023. "Central cavity dehydration as a gating mechanism of potassium channels," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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