IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28142-w.html
   My bibliography  Save this article

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing

Author

Listed:
  • Kishor K. Sivaraj

    (and University of Münster, Faculty of Medicine)

  • Paul-Georg Majev

    (and University of Münster, Faculty of Medicine)

  • Hyun-Woo Jeong

    (and University of Münster, Faculty of Medicine)

  • Backialakshmi Dharmalingam

    (and University of Münster, Faculty of Medicine)

  • Dagmar Zeuschner

    (Electron Microscopy Unit, Max-Planck-Institute for Molecular Biomedicine)

  • Silke Schröder

    (and University of Münster, Faculty of Medicine)

  • M. Gabriele Bixel

    (and University of Münster, Faculty of Medicine)

  • Melanie Timmen

    (University Hospital Münster)

  • Richard Stange

    (University Hospital Münster)

  • Ralf H. Adams

    (and University of Münster, Faculty of Medicine)

Abstract

Developmental osteogenesis, physiological bone remodelling and fracture healing require removal of matrix and cellular debris. Osteoclasts generated by the fusion of circulating monocytes degrade bone, whereas the identity of the cells responsible for cartilage resorption is a long-standing and controversial question. Here we show that matrix degradation and chondrocyte phagocytosis are mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which have a mesenchymal origin and are not derived from haematopoietic cells. The Notch ligand Delta-like 4, provided by endothelial cells, is necessary for septoclast specification and developmental bone growth. Consistent with the termination of growth, septoclasts disappear in adult and ageing bone, but re-emerge in association with growing vessels during fracture healing. We propose that cartilage degradation is mediated by rare, specialized cells distinct from osteoclasts. Our findings have implications for fracture healing, which is frequently impaired in aging humans.

Suggested Citation

  • Kishor K. Sivaraj & Paul-Georg Majev & Hyun-Woo Jeong & Backialakshmi Dharmalingam & Dagmar Zeuschner & Silke Schröder & M. Gabriele Bixel & Melanie Timmen & Richard Stange & Ralf H. Adams, 2022. "Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28142-w
    DOI: 10.1038/s41467-022-28142-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28142-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28142-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. M. Gabriele Bixel & Kishor K. Sivaraj & Melanie Timmen & Vishal Mohanakrishnan & Anusha Aravamudhan & Susanne Adams & Bong-Ihn Koh & Hyun-Woo Jeong & Kai Kruse & Richard Stange & Ralf H. Adams, 2024. "Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28142-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.