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Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism

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Listed:
  • Binyamin Duethorn

    (Max Planck Institute for Molecular Biomedicine)

  • Fabian Groll

    (Max Planck Institute for Molecular Biomedicine)

  • Bettina Rieger

    (Institut für Integrative Zellbiologie und Physiologie, University of Münster)

  • Hannes C. A. Drexler

    (Max Planck Institute for Molecular Biomedicine)

  • Heike Brinkmann

    (Max Planck Institute for Molecular Biomedicine)

  • Ludmila Kremer

    (Max Planck Institute for Molecular Biomedicine)

  • Martin Stehling

    (Max Planck Institute for Molecular Biomedicine)

  • Marie-Theres Borowski

    (Institut für Integrative Zellbiologie und Physiologie, University of Münster)

  • Karina Mildner

    (Max Planck Institute for Molecular Biomedicine)

  • Dagmar Zeuschner

    (Max Planck Institute for Molecular Biomedicine)

  • Magdalena Zernicka-Goetz

    (University of Cambridge
    California Institute of Technology (Caltech))

  • Marc P. Stemmler

    (FAU University Erlangen-Nürnberg)

  • Karin B. Busch

    (Institut für Integrative Zellbiologie und Physiologie, University of Münster)

  • Juan M. Vaquerizas

    (Max Planck Institute for Molecular Biomedicine
    MRC London Institute of Medical Sciences
    Institute of Clinical Sciences, Faculty of Medicine, Imperial College London)

  • Ivan Bedzhov

    (Max Planck Institute for Molecular Biomedicine)

Abstract

Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the expression pattern and examined the function of Lima1 in mouse embryos and pluripotent stem cell lines. We identify that Lima1 expression is controlled by the naïve pluripotency circuit and is required for the suppression of membrane blebbing, as well as for proper mitochondrial energetics in embryonic stem cells. Moreover, forcing Lima1 expression enables primed mouse and human pluripotent stem cells to be incorporated into murine pre-implantation embryos. Thus, Lima1 is a key effector molecule that mediates the pluripotency control of membrane dynamics and cellular metabolism.

Suggested Citation

  • Binyamin Duethorn & Fabian Groll & Bettina Rieger & Hannes C. A. Drexler & Heike Brinkmann & Ludmila Kremer & Martin Stehling & Marie-Theres Borowski & Karina Mildner & Dagmar Zeuschner & Magdalena Ze, 2022. "Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28139-5
    DOI: 10.1038/s41467-022-28139-5
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    References listed on IDEAS

    as
    1. Rui Fan & Yung Su Kim & Jie Wu & Rui Chen & Dagmar Zeuschner & Karina Mildner & Kenjiro Adachi & Guangming Wu & Styliani Galatidou & Jianhua Li & Hans R. Schöler & Sebastian A. Leidel & Ivan Bedzhov, 2020. "Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
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