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Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions

Author

Listed:
  • Ming Zhang

    (Shanxi University)

  • Rammile Ettelaie

    (University of Leeds)

  • Lianlian Dong

    (Shanxi University)

  • Xiaolong Li

    (Shanxi University)

  • Ting Li

    (Shanxi University)

  • Xiaoming Zhang

    (Shanxi University)

  • Bernard P. Binks

    (University of Hull)

  • Hengquan Yang

    (Shanxi University
    Institute of Molecular Science, Shanxi University)

Abstract

A continuous flow cascade of multi-step catalytic reactions is a cutting-edge concept to revolutionize stepwise catalytic synthesis yet is still challenging in practical applications. Herein, a method for practical one-pot cascade catalysis is developed by combining Pickering emulsions with continuous flow. Our method involves co-localization of different catalytically active sub-compartments within droplets of a Pickering emulsion yielding cell-like microreactors, which can be packed in a column reactor for continuous flow cascade catalysis. As exemplified by two chemo-enzymatic cascade reactions for the synthesis of chiral cyanohydrins and chiral ester, 5 − 420 fold enhancement in the catalysis efficiency and as high as 99% enantioselectivity were obtained even over a period of 80 − 240 h. The compartmentalization effect and enriching-reactant properties arising from the biomimetic microreactor are theoretically and experimentally identified as the key factors for boosting the catalysis efficiency and for regulating the kinetics of cascade catalysis.

Suggested Citation

  • Ming Zhang & Rammile Ettelaie & Lianlian Dong & Xiaolong Li & Ting Li & Xiaoming Zhang & Bernard P. Binks & Hengquan Yang, 2022. "Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28100-6
    DOI: 10.1038/s41467-022-28100-6
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    Cited by:

    1. Huanqing Cui & Yage Zhang & Sihan Liu & Yang Cao & Qingming Ma & Yuan Liu & Haisong Lin & Chang Li & Yang Xiao & Sammer Ul Hassan & Ho Cheung Shum, 2024. "Thermo-responsive aqueous two-phase system for two-level compartmentalization," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Danping Tian & Ruipeng Hao & Xiaoming Zhang & Hu Shi & Yuwei Wang & Linfeng Liang & Haichao Liu & Hengquan Yang, 2023. "Multi-compartmental MOF microreactors derived from Pickering double emulsions for chemo-enzymatic cascade catalysis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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