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Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

Author

Listed:
  • Sara M. Hendrickson

    (Oregon Health & Science University)

  • Archana Thomas

    (Oregon Health & Science University)

  • Kamm Prongay

    (Oregon Health & Science University)

  • Andrew J. Haertel

    (Oregon Health & Science University)

  • Laura M. Garzel

    (University of California, Davis)

  • Leanne Gill

    (University of California, Davis)

  • Tasha Barr

    (University of California Irvine)

  • Nicholas S. Rhoades

    (University of California Irvine)

  • Rachel Reader

    (University of California, Davis)

  • Mark Galan

    (Rutgers, New Jersey Medical School)

  • Julie M. Carroll

    (Oregon Health & Science University)

  • Charles T. Roberts

    (Oregon Health & Science University)

  • Lina Gao

    (Knight Cancer Institute)

  • Ian J. Amanna

    (Najít Technologies, Inc.)

  • Ilhem Messaoudi

    (University of California Irvine)

  • Mark K. Slifka

    (Oregon Health & Science University)

Abstract

Environmental enteric dysfunction is associated with malnutrition as well as infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, and inflammation in the small intestine. Here, we characterized environmental enteric dysfunction among infant rhesus macaques that are naturally exposed to enteric pathogens commonly linked to human growth stunting. Remarkably, despite villous atrophy and histological abnormalities observed in the small intestine, poor growth trajectories and low serum tryptophan levels were correlated with increased histopathology in the large intestine. This work provides insight into the mechanisms underlying this disease and indicates that the large intestine may be an important target for therapeutic intervention.

Suggested Citation

  • Sara M. Hendrickson & Archana Thomas & Kamm Prongay & Andrew J. Haertel & Laura M. Garzel & Leanne Gill & Tasha Barr & Nicholas S. Rhoades & Rachel Reader & Mark Galan & Julie M. Carroll & Charles T. , 2022. "Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27925-x
    DOI: 10.1038/s41467-021-27925-x
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    Cited by:

    1. Sara M. Hendrickson & Archana Thomas & Hans-Peter Raué & Kamm Prongay & Andrew J. Haertel & Nicholas S. Rhoades & Jacob F. Slifka & Lina Gao & Benjamin K. Quintel & Ian J. Amanna & Ilhem Messaoudi & M, 2023. "Campylobacter vaccination reduces diarrheal disease and infant growth stunting among rhesus macaques," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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