IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-021-27887-0.html
   My bibliography  Save this article

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Author

Listed:
  • Mehmet Sait Albayram

    (University of Florida, College of Medicine)

  • Garrett Smith

    (University of Florida, College of Medicine)

  • Fatih Tufan

    (Geriatrician (PP), Silivrikapi Mh. Hisaralti Cd)

  • Ibrahim Sacit Tuna

    (University of Florida, College of Medicine)

  • Mehmet Bostancıklıoğlu

    (Elysium Health Center)

  • Michael Zile

    (Medical University of South Carolina
    Ralph H. Johnson Department of Veterans Affairs Medical Center)

  • Onder Albayram

    (Medical University of South Carolina
    Medical University of South Carolina
    Medical University of South Carolina)

Abstract

Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral regions in the human brain. 3D T2-Fluid Attenuated Inversion Recovery magnetic resonance imaging relies on internal signals of protein rich lymphatic fluid rather than contrast media and is used in the present study to visualize the major human dural lymphatic structures. Moreover we detect direct connections between lymphatic fluid channels along the cranial nerves and vascular structures and the cervical lymph nodes. We also identify age-related cervical lymph node atrophy and thickening of lymphatics channels in both dorsal and ventral regions, findings which reflect the reduced lymphatic output of the aged brain.

Suggested Citation

  • Mehmet Sait Albayram & Garrett Smith & Fatih Tufan & Ibrahim Sacit Tuna & Mehmet Bostancıklıoğlu & Michael Zile & Onder Albayram, 2022. "Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27887-0
    DOI: 10.1038/s41467-021-27887-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27887-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27887-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shinji Naganawa & Yutaka Kato & Tadao Yoshida & Michihiko Sone, 2023. "Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    2. Geir Ringstad & Per Kristian Eide, 2023. "The pitfalls of interpreting hyperintense FLAIR signal as lymph outside the human brain," Nature Communications, Nature, vol. 14(1), pages 1-3, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27887-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.