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MyoD is a 3D genome structure organizer for muscle cell identity

Author

Listed:
  • Ruiting Wang

    (Peking Union Medical College)

  • Fengling Chen

    (Tsinghua University)

  • Qian Chen

    (Peking Union Medical College)

  • Xin Wan

    (Peking Union Medical College)

  • Minglei Shi

    (Tsinghua University)

  • Antony K. Chen

    (Peking University)

  • Zhao Ma

    (Peking University
    Peking University)

  • Guohong Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Science)

  • Min Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Science)

  • Yachen Ying

    (Peking University
    Peking University)

  • Qinyao Liu

    (Peking Union Medical College)

  • Hu Li

    (Peking Union Medical College
    Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory))

  • Xu Zhang

    (Beijing institute of collaborative innovation)

  • Jinbiao Ma

    (Fudan University)

  • Jiayun Zhong

    (Fudan University)

  • Meihong Chen

    (Peking Union Medical College)

  • Michael Q. Zhang

    (Tsinghua University
    Tsinghua University
    The University of Texas)

  • Yong Zhang

    (Peking Union Medical College)

  • Yang Chen

    (Peking Union Medical College
    Tsinghua University
    Tsinghua University)

  • Dahai Zhu

    (Peking Union Medical College
    Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory))

Abstract

The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity. An unresolved question is how cell type-specific 3D genome structures are established during development. Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of MyoD-induced chromatin loops in muscle cells. Moreover, we present evidence that other cell lineage-specific TFs might also exert functional roles in orchestrating lineage-specific 3D genome organization during development.

Suggested Citation

  • Ruiting Wang & Fengling Chen & Qian Chen & Xin Wan & Minglei Shi & Antony K. Chen & Zhao Ma & Guohong Li & Min Wang & Yachen Ying & Qinyao Liu & Hu Li & Xu Zhang & Jinbiao Ma & Jiayun Zhong & Meihong , 2022. "MyoD is a 3D genome structure organizer for muscle cell identity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27865-6
    DOI: 10.1038/s41467-021-27865-6
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    Cited by:

    1. Xiaodi Hu & Mingwei Sun & Qian Chen & Yixia Zhao & Na Liang & Siyuan Wang & Pengbin Yin & Yuanping Yang & Sin Man Lam & Qianying Zhang & Alimujiang Tudiyusufu & Yingying Gu & Xin Wan & Meihong Chen & , 2023. "Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Fangfang Qu & Wenjia Li & Jian Xu & Ruifang Zhang & Jincan Ke & Xiaodie Ren & Xiaogao Meng & Lexin Qin & Jingna Zhang & Fangru Lu & Xin Zhou & Xi Luo & Zhen Zhang & Minhan Wang & Guangming Wu & Duanqi, 2023. "Three-dimensional molecular architecture of mouse organogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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