IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-021-27794-4.html
   My bibliography  Save this article

Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

Author

Listed:
  • Qianqian Shi

    (Tianjin Medical University Cancer Institute and Hospital)

  • Kang Shao

    (BGI-Shenzhen
    Zhengzhou University)

  • Hongqin Jia

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer)

  • Boyang Cao

    (BGI-Shenzhen
    Zhengzhou University)

  • Weidong Li

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Shichen Dong

    (BGI-Shenzhen
    Zhengzhou University)

  • Jian Liu

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Kailiang Wu

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Meng Liu

    (BGI-Shenzhen
    Zhengzhou University)

  • Fangfang Liu

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Hanlin Zhou

    (BGI-Shenzhen
    Zhengzhou University)

  • Jianke Lv

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Feng Gu

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Luyuan Li

    (Nankai University)

  • Shida Zhu

    (BGI-Shenzhen
    Zhengzhou University)

  • Shuai Li

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

  • Guibo Li

    (BGI-Shenzhen
    Zhengzhou University
    Shenzhen Key Laboratory of Single-Cell Omics)

  • Li Fu

    (Tianjin Medical University Cancer Institute and Hospital
    National Clinical Research Center for Cancer
    Key Laboratory of Cancer Prevention and Therapy
    Tianjin’s Clinical Research Center for Cancer)

Abstract

Invasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell clusters in multiple lymph node foci arise from a single subclone of the primary tumor. We find evidence that the monoclonal metastatic ancestor in primary IMPC shares high frequency copy-number loss of PRDM16 and IGSF9 and the copy number gain of ALDH2. Immunohistochemistry analysis further shows that low expression of IGSF9 and PRDM16 and high expression of ALDH2 are associated with lymph node metastasis and poor survival of patients with IMPC. We expect these genomic and evolutionary profiles to contribute to the accurate diagnosis of IMPC.

Suggested Citation

  • Qianqian Shi & Kang Shao & Hongqin Jia & Boyang Cao & Weidong Li & Shichen Dong & Jian Liu & Kailiang Wu & Meng Liu & Fangfang Liu & Hanlin Zhou & Jianke Lv & Feng Gu & Luyuan Li & Shida Zhu & Shuai L, 2022. "Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27794-4
    DOI: 10.1038/s41467-021-27794-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27794-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27794-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27794-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.