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Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants

Author

Listed:
  • Lu Wang

    (The State University of New Jersey
    The State University of New Jersey)

  • Dongmeng Li

    (The State University of New Jersey
    The State University of New Jersey)

  • Kezhen Yang

    (Key Laboratory of Plant Molecular Physiology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Botany, Chinese Academy of Sciences)

  • Xiaoyu Guo

    (The State University of New Jersey)

  • Chao Bian

    (The State University of New Jersey
    The State University of New Jersey
    University of California, Davis)

  • Takeshi Nishimura

    (National Institute for Basic Biology, Myodaiji)

  • Jie Le

    (Key Laboratory of Plant Molecular Physiology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Botany, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Miyo Terao Morita

    (National Institute for Basic Biology, Myodaiji)

  • Dominique C. Bergmann

    (Stanford University
    Howard Hughes Medical Institute)

  • Juan Dong

    (The State University of New Jersey
    The State University of New Jersey)

Abstract

Cell polarity is a fundamental feature underlying cell morphogenesis and organismal development. In the Arabidopsis stomatal lineage, the polarity protein BASL controls stomatal asymmetric cell division. However, the cellular machinery by which this intrinsic polarity site is established remains unknown. Here, we identify the PRAF/RLD proteins as BASL physical partners and mutating four PRAF members leads to defects in BASL polarization. Members of PRAF proteins are polarized in stomatal lineage cells in a BASL-dependent manner. Developmental defects of the praf mutants phenocopy those of the gnom mutants. GNOM is an activator of the conserved Arf GTPases and plays important roles in membrane trafficking. We further find PRAF physically interacts with GNOM in vitro and in vivo. Thus, we propose that the positive feedback of BASL and PRAF at the plasma membrane and the connected function of PRAF and GNOM in endosomal trafficking establish intrinsic cell polarity in the Arabidopsis stomatal lineage.

Suggested Citation

  • Lu Wang & Dongmeng Li & Kezhen Yang & Xiaoyu Guo & Chao Bian & Takeshi Nishimura & Jie Le & Miyo Terao Morita & Dominique C. Bergmann & Juan Dong, 2022. "Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27748-w
    DOI: 10.1038/s41467-021-27748-w
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    Cited by:

    1. Linsan Liu & Sarah B. Jose & Chiara Campoli & Micha M. Bayer & Miguel A. Sánchez-Diaz & Trisha McAllister & Yichun Zhou & Mhmoud Eskan & Linda Milne & Miriam Schreiber & Thomas Batstone & Ian D. Bull , 2022. "Conserved signalling components coordinate epidermal patterning and cuticle deposition in barley," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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