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Chirality transmission in macromolecular domains

Author

Listed:
  • Shankar Pandey

    (Kent State University)

  • Shankar Mandal

    (Kent State University)

  • Mathias Bogetoft Danielsen

    (University of Southern Denmark)

  • Asha Brown

    (ATDBio Ltd., Magdalen Centre, Oxford Science Park)

  • Changpeng Hu

    (Kent State University)

  • Niels Johan Christensen

    (University of Copenhagen)

  • Alina Vitaliyivna Kulakova

    (University of Copenhagen)

  • Shixi Song

    (University of Southern Denmark)

  • Tom Brown

    (University of Oxford)

  • Knud J. Jensen

    (University of Copenhagen)

  • Jesper Wengel

    (University of Southern Denmark)

  • Chenguang Lou

    (University of Southern Denmark)

  • Hanbin Mao

    (Kent State University)

Abstract

Chiral communications exist in secondary structures of foldamers and copolymers via a network of noncovalent interactions within effective intermolecular force (IMF) range. It is not known whether long-range chiral communication exists between macromolecular tertiary structures such as peptide coiled-coils beyond the IMF distance. Harnessing the high sensitivity of single-molecule force spectroscopy, we investigate the chiral interaction between covalently linked DNA duplexes and peptide coiled-coils by evaluating the binding of a diastereomeric pair of three DNA-peptide conjugates. We find that right-handed DNA triple helices well accommodate peptide triple coiled-coils of the same handedness, but not with the left-handed coiled-coil stereoisomers. This chiral communication is effective in a range (

Suggested Citation

  • Shankar Pandey & Shankar Mandal & Mathias Bogetoft Danielsen & Asha Brown & Changpeng Hu & Niels Johan Christensen & Alina Vitaliyivna Kulakova & Shixi Song & Tom Brown & Knud J. Jensen & Jesper Wenge, 2022. "Chirality transmission in macromolecular domains," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27708-4
    DOI: 10.1038/s41467-021-27708-4
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    References listed on IDEAS

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    1. Andrew J. Neel & Margaret J. Hilton & Matthew S. Sigman & F. Dean Toste, 2017. "Exploiting non-covalent π interactions for catalyst design," Nature, Nature, vol. 543(7647), pages 637-646, March.
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    Cited by:

    1. Deepak Karna & Eriko Mano & Jiahao Ji & Ibuki Kawamata & Yuki Suzuki & Hanbin Mao, 2023. "Chemo-mechanical forces modulate the topology dynamics of mesoscale DNA assemblies," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jana Bocková & Nykola C. Jones & Jérémie Topin & Søren V. Hoffmann & Cornelia Meinert, 2023. "Uncovering the chiral bias of meteoritic isovaline through asymmetric photochemistry," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Zhentao Sang & Lu Xu & Renyu Ding & Minjun Wang & Xiaoran Yang & Xitan Li & Bingxin Zhou & Kaijun Gou & Yang Han & Tingting Liu & Xuchun Chen & Ying Cheng & Huazhe Yang & Heran Li, 2023. "Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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