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Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Author

Listed:
  • Anaïs Eskenazi

    (CUB-Erasme Hospital
    Centre Hospitalier de Cayenne)

  • Cédric Lood

    (KU Leuven
    KU Leuven)

  • Julia Wubbolts

    (Leiden University Medical Centre)

  • Maya Hites

    (CUB-Erasme Hospital)

  • Nana Balarjishvili

    (Microbiology and Virology)

  • Lika Leshkasheli

    (Microbiology and Virology)

  • Lia Askilashvili

    (Microbiology and Virology)

  • Leila Kvachadze

    (Microbiology and Virology)

  • Vera Noort

    (KU Leuven
    Leiden University)

  • Jeroen Wagemans

    (KU Leuven)

  • Marc Jayankura

    (CUB-Erasme Hospital)

  • Nina Chanishvili

    (Microbiology and Virology)

  • Mark Boer

    (Leiden University Medical Centre)

  • Peter Nibbering

    (Leiden University Medical Centre)

  • Mzia Kutateladze

    (Microbiology and Virology)

  • Rob Lavigne

    (KU Leuven)

  • Maya Merabishvili

    (Queen Astrid Military Hospital)

  • Jean-Paul Pirnay

    (Queen Astrid Military Hospital)

Abstract

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions.

Suggested Citation

  • Anaïs Eskenazi & Cédric Lood & Julia Wubbolts & Maya Hites & Nana Balarjishvili & Lika Leshkasheli & Lia Askilashvili & Leila Kvachadze & Vera Noort & Jeroen Wagemans & Marc Jayankura & Nina Chanishvi, 2022. "Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27656-z
    DOI: 10.1038/s41467-021-27656-z
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    Cited by:

    1. Cristina Herencias & Laura Álvaro-Llorente & Paula Ramiro-Martínez & Ariadna Fernández-Calvet & Ada Muñoz-Cazalla & Javier DelaFuente & Fabrice E. Graf & Laura Jaraba-Soto & Juan Antonio Castillo-Polo, 2024. "β-lactamase expression induces collateral sensitivity in Escherichia coli," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Fabian Kunisch & Claudia Campobasso & Jeroen Wagemans & Selma Yildirim & Benjamin K. Chan & Christoph Schaudinn & Rob Lavigne & Paul E. Turner & Michael J. Raschke & Andrej Trampuz & Mercedes Gonzalez, 2024. "Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Dimitri Boeckaerts & Michiel Stock & Celia Ferriol-González & Jesús Oteo-Iglesias & Rafael Sanjuán & Pilar Domingo-Calap & Bernard Baets & Yves Briers, 2024. "Prediction of Klebsiella phage-host specificity at the strain level," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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