IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-021-27602-z.html
   My bibliography  Save this article

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Author

Listed:
  • Arpan Parichha

    (Tata Institute of Fundamental Research)

  • Varun Suresh

    (Tata Institute of Fundamental Research)

  • Mallika Chatterjee

    (Tata Institute of Fundamental Research
    Amity University)

  • Aditya Kshirsagar

    (Weizmann Institute of Science)

  • Lihi Ben-Reuven

    (Weizmann Institute of Science)

  • Tsviya Olender

    (Weizmann Institute of Science)

  • M. Mark Taketo

    (Kyoto University (Yoshida-Konoé-Cho, Sakyo))

  • Velena Radosevic

    (School of Medicine University of Zagreb
    University Hospital Centre Zagreb, Department of Gynecology and Department of Pathology and Cytology)

  • Mihaela Bobic-Rasonja

    (School of Medicine University of Zagreb
    University Hospital Centre Zagreb, Department of Gynecology and Department of Pathology and Cytology)

  • Sara Trnski

    (School of Medicine University of Zagreb)

  • Michael J. Holtzman

    (Washington University)

  • Nataša Jovanov-Milosevic

    (School of Medicine University of Zagreb
    University Hospital Centre Zagreb, Department of Gynecology and Department of Pathology and Cytology)

  • Orly Reiner

    (Weizmann Institute of Science)

  • Shubha Tole

    (Tata Institute of Fundamental Research)

Abstract

The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules such as nuclear β-CATENIN are expressed in the mouse and human embryonic choroid plexus epithelium indicating that this pathway is active. Point mutations in human β-CATENIN are known to result in the constitutive activation of canonical Wnt signaling. In a mouse model that recapitulates this perturbation, we report a loss of choroid plexus epithelial identity and an apparent transformation of this tissue to a neuronal identity. Aspects of this phenomenon are recapitulated in human embryonic stem cell derived organoids. The choroid plexus is also disrupted when β-Catenin is conditionally inactivated. Together, our results indicate that canonical Wnt signaling is required in a precise and regulated manner for normal choroid plexus development in the mammalian brain.

Suggested Citation

  • Arpan Parichha & Varun Suresh & Mallika Chatterjee & Aditya Kshirsagar & Lihi Ben-Reuven & Tsviya Olender & M. Mark Taketo & Velena Radosevic & Mihaela Bobic-Rasonja & Sara Trnski & Michael J. Holtzma, 2022. "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27602-z
    DOI: 10.1038/s41467-021-27602-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27602-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27602-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yan Wu & Jinhao Cheng & Jie Qi & Chen Hang & Ruihua Dong & Boon Chuan Low & Hanry Yu & Xingyu Jiang, 2024. "Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27602-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.