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Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus

Author

Listed:
  • Whitney R. Baldwin

    (Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
    Takeda Vaccines Inc.)

  • Holli A. Giebler

    (Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
    Takeda Vaccines Inc.)

  • Janae L. Stovall

    (Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention)

  • Ginger Young

    (Takeda Vaccines Inc.)

  • Kelly J. Bohning

    (Takeda Vaccines Inc.)

  • Hansi J. Dean

    (Takeda Vaccines Inc.)

  • Jill A. Livengood

    (Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention
    Takeda Vaccines Inc.)

  • Claire Y.-H. Huang

    (Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention)

Abstract

The development of a safe and effective Zika virus (ZIKV) vaccine has become a global health priority since the widespread epidemic in 2015-2016. Based on previous experience in using the well-characterized and clinically proven dengue virus serotype-2 (DENV-2) PDK-53 vaccine backbone for live-attenuated chimeric flavivirus vaccine development, we developed chimeric DENV-2/ZIKV vaccine candidates optimized for growth and genetic stability in Vero cells. These vaccine candidates retain all previously characterized attenuation phenotypes of the PDK-53 vaccine virus, including attenuation of neurovirulence for 1-day-old CD-1 mice, absence of virulence in interferon receptor-deficient mice, and lack of transmissibility in the main mosquito vectors. A single DENV-2/ZIKV dose provides protection against ZIKV challenge in mice and rhesus macaques. Overall, these data indicate that the ZIKV live-attenuated vaccine candidates are safe, immunogenic and effective at preventing ZIKV infection in multiple animal models, warranting continued development.

Suggested Citation

  • Whitney R. Baldwin & Holli A. Giebler & Janae L. Stovall & Ginger Young & Kelly J. Bohning & Hansi J. Dean & Jill A. Livengood & Claire Y.-H. Huang, 2021. "Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27578-w
    DOI: 10.1038/s41467-021-27578-w
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