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Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation

Author

Listed:
  • Mergim Ramosaj

    (University of Lausanne)

  • Sofia Madsen

    (University of Lausanne)

  • Vanille Maillard

    (University of Lausanne)

  • Valentina Scandella

    (University of Lausanne)

  • Daniel Sudria-Lopez

    (University of Lausanne)

  • Naoya Yuizumi

    (The University of Tokyo)

  • Ludovic Telley

    (University of Lausanne)

  • Marlen Knobloch

    (University of Lausanne)

Abstract

Neural stem/progenitor cells (NSPCs) generate new neurons throughout adulthood. However, the underlying regulatory processes are still not fully understood. Lipid metabolism plays an important role in regulating NSPC activity: build-up of lipids is crucial for NSPC proliferation, whereas break-down of lipids has been shown to regulate NSPC quiescence. Despite their central role for cellular lipid metabolism, the role of lipid droplets (LDs), the lipid storing organelles, in NSPCs remains underexplored. Here we show that LDs are highly abundant in adult mouse NSPCs, and that LD accumulation is significantly altered upon fate changes such as quiescence and differentiation. NSPC proliferation is influenced by the number of LDs, inhibition of LD build-up, breakdown or usage, and the asymmetric inheritance of LDs during mitosis. Furthermore, high LD-containing NSPCs have increased metabolic activity and capacity, but do not suffer from increased oxidative damage. Together, these data indicate an instructive role for LDs in driving NSPC behaviour.

Suggested Citation

  • Mergim Ramosaj & Sofia Madsen & Vanille Maillard & Valentina Scandella & Daniel Sudria-Lopez & Naoya Yuizumi & Ludovic Telley & Marlen Knobloch, 2021. "Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27365-7
    DOI: 10.1038/s41467-021-27365-7
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    References listed on IDEAS

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    1. Semir Beyaz & Miyeko D. Mana & Jatin Roper & Dmitriy Kedrin & Assieh Saadatpour & Sue-Jean Hong & Khristian E. Bauer-Rowe & Michael E. Xifaras & Adam Akkad & Erika Arias & Luca Pinello & Yarden Katz &, 2016. "High-fat diet enhances stemness and tumorigenicity of intestinal progenitors," Nature, Nature, vol. 531(7592), pages 53-58, March.
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    Cited by:

    1. Dianne Lumaquin-Yin & Emily Montal & Eleanor Johns & Arianna Baggiolini & Ting-Hsiang Huang & Yilun Ma & Charlotte LaPlante & Shruthy Suresh & Lorenz Studer & Richard M. White, 2023. "Lipid droplets are a metabolic vulnerability in melanoma," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Sofia Madsen & Ana C. Delgado & Christelle Cadilhac & Vanille Maillard & Fabrice Battiston & Carla Marie Igelbüscher & Simon De Neck & Elia Magrinelli & Denis Jabaudon & Ludovic Telley & Fiona Doetsch, 2024. "A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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