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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Author

Listed:
  • Olusegun Isaac Alatise

    (Obafemi Awolowo University)

  • Gregory C. Knapp

    (Memorial Sloan Kettering Cancer Center
    Dalhousie University)

  • Avinash Sharma

    (Memorial Sloan Kettering Cancer Center)

  • Walid K. Chatila

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

  • Olukayode A. Arowolo

    (Obafemi Awolowo University)

  • Olalekan Olasehinde

    (Obafemi Awolowo University)

  • Olusola C. Famurewa

    (Obafemi Awolowo University)

  • Adeleye D. Omisore

    (Obafemi Awolowo University)

  • Akinwumi O. Komolafe

    (Obafemi Awolowo University)

  • Olaejinrinde O. Olaofe

    (Obafemi Awolowo University)

  • Aba I. Katung

    (Federal Medical Centre)

  • David E. Ibikunle

    (Federal Medical Centre)

  • Adedeji A. Egberongbe

    (Federal Medical Centre)

  • Samuel A. Olatoke

    (University of Ilorin Teaching Hospital)

  • Sulaiman O. Agodirin

    (University of Ilorin Teaching Hospital)

  • Olusola A. Adesiyun

    (University of Ilorin Teaching Hospital)

  • Ademola Adeyeye

    (University of Ilorin Teaching Hospital)

  • Oladapo A. Kolawole

    (Ladoke Akintola University of Technology)

  • Akinwumi O. Olakanmi

    (University of Medical Sciences)

  • Kanika Arora

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Jeremy Constable

    (Memorial Sloan Kettering Cancer Center)

  • Ronak Shah

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Azfar Basunia

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Brooke Sylvester

    (Memorial Sloan Kettering Cancer Center)

  • Chao Wu

    (Memorial Sloan Kettering Cancer Center)

  • Martin R. Weiser

    (Memorial Sloan Kettering Cancer Center)

  • Ken Seier

    (Memorial Sloan Kettering Cancer Center)

  • Mithat Gonen

    (Memorial Sloan Kettering Cancer Center)

  • Zsofia K. Stadler

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Yelena Kemel

    (Memorial Sloan Kettering Cancer Center)

  • Efsevia Vakiani

    (Memorial Sloan Kettering Cancer Center)

  • Michael F. Berger

    (Memorial Sloan Kettering Cancer Center)

  • Timothy A. Chan

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • David B. Solit

    (Memorial Sloan Kettering Cancer Center)

  • Jinru Shia

    (Memorial Sloan Kettering Cancer Center)

  • Francisco Sanchez-Vega

    (Memorial Sloan Kettering Cancer Center)

  • Nikolaus Schultz

    (Memorial Sloan Kettering Cancer Center)

  • Murray Brennan

    (Memorial Sloan Kettering Cancer Center)

  • J. Joshua Smith

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • T. Peter Kingham

    (Memorial Sloan Kettering Cancer Center)

Abstract

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P

Suggested Citation

  • Olusegun Isaac Alatise & Gregory C. Knapp & Avinash Sharma & Walid K. Chatila & Olukayode A. Arowolo & Olalekan Olasehinde & Olusola C. Famurewa & Adeleye D. Omisore & Akinwumi O. Komolafe & Olaejinri, 2021. "Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27106-w
    DOI: 10.1038/s41467-021-27106-w
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    References listed on IDEAS

    as
    1. Mariangela Russo & Simona Lamba & Annalisa Lorenzato & Alberto Sogari & Giorgio Corti & Giuseppe Rospo & Benedetta Mussolin & Monica Montone & Luca Lazzari & Sabrina Arena & Daniele Oddo & Michael Lin, 2018. "Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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