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Thermoresponsive polymer assemblies via variable temperature liquid-phase transmission electron microscopy and small angle X-ray scattering

Author

Listed:
  • Joanna Korpanty

    (Northwestern University)

  • Lucas R. Parent

    (University of Connecticut)

  • Nicholas Hampu

    (Northwestern University)

  • Steven Weigand

    (Northwestern University)

  • Nathan C. Gianneschi

    (Northwestern University
    Northwestern University
    Northwestern University)

Abstract

Herein, phase transitions of a class of thermally-responsive polymers, namely a homopolymer, diblock, and triblock copolymer, were studied to gain mechanistic insight into nanoscale assembly dynamics via variable temperature liquid-cell transmission electron microscopy (VT-LCTEM) correlated with variable temperature small angle X-ray scattering (VT-SAXS). We study thermoresponsive poly(diethylene glycol methyl ether methacrylate) (PDEGMA)-based block copolymers and mitigate sample damage by screening electron flux and solvent conditions during LCTEM and by evaluating polymer survival via post-mortem matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). Our multimodal approach, utilizing VT-LCTEM with MS validation and VT-SAXS, is generalizable across polymeric systems and can be used to directly image solvated nanoscale structures and thermally-induced transitions. Our strategy of correlating VT-SAXS with VT-LCTEM provided direct insight into transient nanoscale intermediates formed during the thermally-triggered morphological transformation of a PDEGMA-based triblock. Notably, we observed the temperature-triggered formation and slow relaxation of core-shell particles with complex microphase separation in the core by both VT-SAXS and VT-LCTEM.

Suggested Citation

  • Joanna Korpanty & Lucas R. Parent & Nicholas Hampu & Steven Weigand & Nathan C. Gianneschi, 2021. "Thermoresponsive polymer assemblies via variable temperature liquid-phase transmission electron microscopy and small angle X-ray scattering," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26773-z
    DOI: 10.1038/s41467-021-26773-z
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    References listed on IDEAS

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    1. Mollie A. Touve & Andrea S. Carlini & Nathan C. Gianneschi, 2019. "Self-assembling peptides imaged by correlated liquid cell transmission electron microscopy and MALDI-imaging mass spectrometry," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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    Cited by:

    1. Joanna Korpanty & Cheng Wang & Nathan C. Gianneschi, 2023. "Upper critical solution temperature polymer assemblies via variable temperature liquid phase transmission electron microscopy and liquid resonant soft X-ray scattering," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Stefan Merkens & Christopher Tollan & Giuseppe Salvo & Katarzyna Bejtka & Marco Fontana & Angelica Chiodoni & Joscha Kruse & Maiara Aime Iriarte-Alonso & Marek Grzelczak & Andreas Seifert & Andrey Chu, 2024. "Toward sub-second solution exchange dynamics in flow reactors for liquid-phase transmission electron microscopy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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    1. Joanna Korpanty & Cheng Wang & Nathan C. Gianneschi, 2023. "Upper critical solution temperature polymer assemblies via variable temperature liquid phase transmission electron microscopy and liquid resonant soft X-ray scattering," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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