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BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women

Author

Listed:
  • Michal Rosenberg-Friedman

    (Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center
    Tel Aviv University)

  • Aya Kigel

    (Tel Aviv University)

  • Yael Bahar

    (Tel Aviv University)

  • Michal Werbner

    (Bar-Ilan University)

  • Joel Alter

    (Bar-Ilan University)

  • Yariv Yogev

    (Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center
    Tel Aviv University)

  • Yael Dror

    (Tel Aviv University)

  • Ronit Lubetzky

    (Tel Aviv University
    Dana Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center)

  • Moshe Dessau

    (Bar-Ilan University)

  • Meital Gal-Tanamy

    (Bar-Ilan University)

  • Ariel Many

    (Lis Maternity & Women’s Hospital, Tel Aviv Sourasky Medical Center
    Tel Aviv University)

  • Yariv Wine

    (Tel Aviv University)

Abstract

The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity.

Suggested Citation

  • Michal Rosenberg-Friedman & Aya Kigel & Yael Bahar & Michal Werbner & Joel Alter & Yariv Yogev & Yael Dror & Ronit Lubetzky & Moshe Dessau & Meital Gal-Tanamy & Ariel Many & Yariv Wine, 2021. "BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26507-1
    DOI: 10.1038/s41467-021-26507-1
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    Cited by:

    1. Kevin J. Kramer & Erin M. Wilfong & Kelsey Voss & Sierra M. Barone & Andrea R. Shiakolas & Nagarajan Raju & Caroline E. Roe & Naveenchandra Suryadevara & Lauren M. Walker & Steven C. Wall & Ariana Pau, 2022. "Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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