IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26448-9.html
   My bibliography  Save this article

Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

Author

Listed:
  • Xing Liu

    (Harvard University
    Fudan University)

  • Wanshui Yang

    (Brigham and Women’s Hospital and Harvard Medical School
    Anhui Medical University)

  • Jessica L. Petrick

    (Boston University)

  • Linda M. Liao

    (National Cancer Institute)

  • Weibing Wang

    (Fudan University)

  • Na He

    (Fudan University)

  • Peter T. Campbell

    (American Cancer Society)

  • Zuo-Feng Zhang

    (University of California
    UCLA)

  • Edward Giovannucci

    (Harvard University
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard University)

  • Katherine A. McGlynn

    (National Cancer Institute)

  • Xuehong Zhang

    (Harvard University
    Brigham and Women’s Hospital and Harvard Medical School)

Abstract

The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health–American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995–1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63–0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35–0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53–0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29–0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.

Suggested Citation

  • Xing Liu & Wanshui Yang & Jessica L. Petrick & Linda M. Liao & Weibing Wang & Na He & Peter T. Campbell & Zuo-Feng Zhang & Edward Giovannucci & Katherine A. McGlynn & Xuehong Zhang, 2021. "Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26448-9
    DOI: 10.1038/s41467-021-26448-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26448-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26448-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhening Liu & Hangkai Huang & Jiarong Xie & Yingying Xu & Chengfu Xu, 2024. "Circulating fatty acids and risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26448-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.