IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26400-x.html
   My bibliography  Save this article

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

Author

Listed:
  • Janek S. Walker

    (The Ohio State University)

  • Zachary A. Hing

    (The Ohio State University)

  • Steven Sher

    (The Ohio State University)

  • James Cronin

    (The Ohio State University
    The Ohio State University)

  • Katie Williams

    (The Ohio State University)

  • Bonnie Harrington

    (The Ohio State University)

  • Jordan N. Skinner

    (The Ohio State University)

  • Casey B. Cempre

    (The Ohio State University)

  • Charles T. Gregory

    (The Ohio State University)

  • Alexander Pan

    (The Ohio State University)

  • Max Yano

    (The Ohio State University)

  • Larry P. Beaver

    (The Ohio State University)

  • Brandi R. Walker

    (The Ohio State University)

  • Jadwiga M. Labanowska

    (The Ohio State University)

  • Nyla A. Heerema

    (The Ohio State University)

  • Krzysztof Mrózek

    (The Ohio State University)

  • Jennifer A. Woyach

    (The Ohio State University)

  • Amy S. Ruppert

    (The Ohio State University)

  • Amy Lehman

    (The Ohio State University)

  • Hatice Gulcin Ozer

    (The Ohio State University College of Medicine)

  • Vincenzo Coppola

    (The Ohio State University College of Medicine
    The Ohio State University and Arthur G. James Comprehensive Cancer Center)

  • Pearlly Yan

    (The Ohio State University)

  • John C. Byrd

    (The Ohio State University
    The Ohio State University)

  • James S. Blachly

    (The Ohio State University
    The Ohio State University College of Medicine)

  • Rosa Lapalombella

    (The Ohio State University)

Abstract

Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but have led to the discovery of pathogenic genes including CCND1, BCL2, and BCL3. Following identification of a t(X;14)(q28;q32) translocation that placed the mature T cell proliferation 1 gene (MTCP1) adjacent to the immunoglobulin locus in a CLL patient, we hypothesized that this gene may have previously unrecognized importance. Indeed, here we report overexpression of human MTCP1 restricted to the B cell compartment in mice produces a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human CLL and demonstrates favorable response to therapeutic intervention with ibrutinib. We reinforce the importance of genetic interrogation of rare, recurrent balanced translocations to identify cancer driving genes via the story of MTCP1 as a contributor to CLL pathogenesis.

Suggested Citation

  • Janek S. Walker & Zachary A. Hing & Steven Sher & James Cronin & Katie Williams & Bonnie Harrington & Jordan N. Skinner & Casey B. Cempre & Charles T. Gregory & Alexander Pan & Max Yano & Larry P. Bea, 2021. "Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26400-x
    DOI: 10.1038/s41467-021-26400-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26400-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26400-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Dan A. Landau & Eugen Tausch & Amaro N. Taylor-Weiner & Chip Stewart & Johannes G. Reiter & Jasmin Bahlo & Sandra Kluth & Ivana Bozic & Mike Lawrence & Sebastian Böttcher & Scott L. Carter & Kristian , 2015. "Mutations driving CLL and their evolution in progression and relapse," Nature, Nature, vol. 526(7574), pages 525-530, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sophie A. Herbst & Mattias Vesterlund & Alexander J. Helmboldt & Rozbeh Jafari & Ioannis Siavelis & Matthias Stahl & Eva C. Schitter & Nora Liebers & Berit J. Brinkmann & Felix Czernilofsky & Tobias R, 2022. "Proteogenomics refines the molecular classification of chronic lymphocytic leukemia," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Maurizio Mangolini & Alba Maiques-Diaz & Stella Charalampopoulou & Elena Gerhard-Hartmann & Johannes Bloehdorn & Andrew Moore & Giorgia Giachetti & Junyan Lu & Valar Nila Roamio Franklin & Chandra Sek, 2022. "Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Othman Al-Sawaf & Can Zhang & Hyun Yong Jin & Sandra Robrecht & Yoonha Choi & Sandhya Balasubramanian & Alex Kotak & Yi Meng Chang & Anna Maria Fink & Eugen Tausch & Christof Schneider & Matthias Ritg, 2023. "Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26400-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.