IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26351-3.html
   My bibliography  Save this article

Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

Author

Listed:
  • Young-Jun Ju

    (Seoul National University)

  • Sung-Woo Lee

    (Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology
    Chonnam National University Medical School
    Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasun Hospital)

  • Yoon-Chul Kye

    (Seoul National University)

  • Gil-Woo Lee

    (Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology
    Chonnam National University Medical School
    Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasun Hospital)

  • Hee-Ok Kim

    (Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasun Hospital)

  • Cheol-Heui Yun

    (Seoul National University)

  • Jae-Ho Cho

    (Chonnam National University Medical School
    Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasun Hospital
    BioMedical Sciences Graduate Program, Chonnam National University Medical School)

Abstract

The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8+ T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells. CD5hiLy6C+ cells differ from CD5loLy6C– and CD5hiLy6C– cells in terms of gene expression profiles and functional properties. Moreover, CD5hiLy6C+ cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5hiLy6C+ cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8+ T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8+ T cells by co-opting tonic type I interferon signaling.

Suggested Citation

  • Young-Jun Ju & Sung-Woo Lee & Yoon-Chul Kye & Gil-Woo Lee & Hee-Ok Kim & Cheol-Heui Yun & Jae-Ho Cho, 2021. "Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26351-3
    DOI: 10.1038/s41467-021-26351-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26351-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-26351-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jae-Ho Cho & Hee-Ok Kim & Young-Jun Ju & Yoon-Chul Kye & Gil-Woo Lee & Sung-Woo Lee & Cheol-Heui Yun & Nunzio Bottini & Kylie Webster & Christopher C. Goodnow & Charles D. Surh & Cecile King & Jonatha, 2016. "CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells," Nature Communications, Nature, vol. 7(1), pages 1-15, December.
    2. Jason T. White & Eric W. Cross & Matthew A. Burchill & Thomas Danhorn & Martin D. McCarter & Hugo R. Rosen & Brian O’Connor & Ross M. Kedl, 2016. "Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner," Nature Communications, Nature, vol. 7(1), pages 1-13, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gil-Woo Lee & Young Ju Kim & Sung-Woo Lee & Hee-Ok Kim & Daeun Kim & Jiyoung Kim & You-Me Kim & Keunsoo Kang & Joon Haeng Rhee & Ik Joo Chung & Woo Kyun Bae & In-Jae Oh & Deok Hwan Yang & Jae-Ho Cho, 2024. "Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gil-Woo Lee & Young Ju Kim & Sung-Woo Lee & Hee-Ok Kim & Daeun Kim & Jiyoung Kim & You-Me Kim & Keunsoo Kang & Joon Haeng Rhee & Ik Joo Chung & Woo Kyun Bae & In-Jae Oh & Deok Hwan Yang & Jae-Ho Cho, 2024. "Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Lion F. K. Uhl & Han Cai & Sophia L. Oram & Jagdish N. Mahale & Andrew J. MacLean & Julie M. Mazet & Theo Piccirilli & Alexander J. He & Doreen Lau & Tim Elliott & Audrey Gerard, 2023. "Interferon-γ couples CD8+ T cell avidity and differentiation during infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26351-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.