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A medullary centre for lapping in mice

Author

Listed:
  • Bowen Dempsey

    (PSL Research University)

  • Selvee Sungeelee

    (PSL Research University)

  • Phillip Bokiniec

    (Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), and Neuroscience Research Center, Charité-Universitätsmedizin)

  • Zoubida Chettouh

    (PSL Research University)

  • Séverine Diem

    (Université Paris-Saclay, CNRS, Institut des Neurosciences NeuroPSI)

  • Sandra Autran

    (Université Paris-Saclay, CNRS, Institut des Neurosciences NeuroPSI)

  • Evan R. Harrell

    (Institut Pasteur, INSERM, Institut de l’Audition)

  • James F. A. Poulet

    (Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), and Neuroscience Research Center, Charité-Universitätsmedizin)

  • Carmen Birchmeier

    (Charité-Universitätsmedizin)

  • Harry Carey

    (Macquarie University)

  • Auguste Genovesio

    (PSL Research University)

  • Simon McMullan

    (Macquarie University)

  • Christo Goridis

    (PSL Research University)

  • Gilles Fortin

    (PSL Research University)

  • Jean-François Brunet

    (PSL Research University)

Abstract

It has long been known that orofacial movements for feeding can be triggered, coordinated, and often rhythmically organized at the level of the brainstem, without input from higher centers. We uncover two nuclei that can organize the movements for ingesting fluids in mice. These neuronal groups, IRtPhox2b and Peri5Atoh1, are marked by expression of the pan-autonomic homeobox gene Phox2b and are located, respectively, in the intermediate reticular formation of the medulla and around the motor nucleus of the trigeminal nerve. They are premotor to all jaw-opening and tongue muscles. Stimulation of either, in awake animals, opens the jaw, while IRtPhox2b alone also protracts the tongue. Moreover, stationary stimulation of IRtPhox2b entrains a rhythmic alternation of tongue protraction and retraction, synchronized with jaw opening and closing, that mimics lapping. Finally, fiber photometric recordings show that IRtPhox2b is active during volitional lapping. Our study identifies one of the subcortical nuclei underpinning a stereotyped feeding behavior.

Suggested Citation

  • Bowen Dempsey & Selvee Sungeelee & Phillip Bokiniec & Zoubida Chettouh & Séverine Diem & Sandra Autran & Evan R. Harrell & James F. A. Poulet & Carmen Birchmeier & Harry Carey & Auguste Genovesio & Si, 2021. "A medullary centre for lapping in mice," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26275-y
    DOI: 10.1038/s41467-021-26275-y
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    References listed on IDEAS

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    Cited by:

    1. Laure Lecoin & Bowen Dempsey & Alexandra Garancher & Steeve Bourane & Pierre-Louis Ruffault & Marie-Pierre Morin-Surun & Nathalie Rocques & Martyn Goulding & Alain Eychène & Celio Pouponnot & Gilles F, 2022. "Mafa-dependent GABAergic activity promotes mouse neonatal apneas," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Harry Carey & Michael Pegios & Lewis Martin & Chris Saleeba & Anita J. Turner & Nicholas A. Everett & Ingvild E. Bjerke & Maja A. Puchades & Jan G. Bjaalie & Simon McMullan, 2023. "DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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