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Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders

Author

Listed:
  • Ulrich Flögel

    (Heinrich Heine University
    Heinrich Heine University
    University Hospital Düsseldorf)

  • Sebastian Temme

    (Heinrich Heine University
    Heinrich Heine University
    University Hospital Düsseldorf
    Heinrich Heine University)

  • Christoph Jacoby

    (Heinrich Heine University
    University Hospital Düsseldorf)

  • Thomas Oerther

    (Bruker BioSpin)

  • Petra Keul

    (Heinrich Heine University)

  • Vera Flocke

    (Heinrich Heine University)

  • Xiaowei Wang

    (Baker Heart and Diabetes Institute)

  • Florian Bönner

    (University Hospital Düsseldorf)

  • Fabian Nienhaus

    (University Hospital Düsseldorf)

  • Karlheinz Peter

    (Baker Heart and Diabetes Institute)

  • Jürgen Schrader

    (Heinrich Heine University
    University Hospital Düsseldorf)

  • Maria Grandoch

    (Heinrich Heine University)

  • Malte Kelm

    (Heinrich Heine University
    University Hospital Düsseldorf)

  • Bodo Levkau

    (Heinrich Heine University)

Abstract

Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading to irreversible myocardial damage is still an unsolved problem. Here, we introduce a multi-targeted and multi-color nanotracer platform technology that simultaneously visualizes evolving danger patterns in the development of progressive coronary inflammation and atherothrombosis prior to spontaneous myocardial infarction in mice. Individual ligand-equipped perfluorocarbon nanoemulsions are used as targeting agents and are differentiated by their specific spectral signatures via implementation of multi chemical shift selective 19F MRI. Thereby, we are able to identify areas at high risk of and predictive for consecutive development of myocardial infarction, at a time when no conventional parameter indicates any imminent danger. The principle of this multi-targeted approach can easily be adapted to monitor also a variety of other disease entities and constitutes a technology with disease-predictive potential.

Suggested Citation

  • Ulrich Flögel & Sebastian Temme & Christoph Jacoby & Thomas Oerther & Petra Keul & Vera Flocke & Xiaowei Wang & Florian Bönner & Fabian Nienhaus & Karlheinz Peter & Jürgen Schrader & Maria Grandoch & , 2021. "Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26146-6
    DOI: 10.1038/s41467-021-26146-6
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