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Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Author

Listed:
  • Aljawharah Alrubayyi

    (University of Oxford)

  • Ester Gea-Mallorquí

    (University of Oxford)

  • Emma Touizer

    (University College London)

  • Dan Hameiri-Bowen

    (University of Oxford)

  • Jakub Kopycinski

    (University of Oxford)

  • Bethany Charlton

    (University of Oxford)

  • Natasha Fisher-Pearson

    (University of Oxford)

  • Luke Muir

    (University College London)

  • Annachiara Rosa

    (The Francis Crick Institute)

  • Chloe Roustan

    (The Francis Crick Institute)

  • Christopher Earl

    (Francis Crick Institute)

  • Peter Cherepanov

    (The Francis Crick Institute)

  • Pierre Pellegrino

    (CNWL NHS Trust)

  • Laura Waters

    (CNWL NHS Trust)

  • Fiona Burns

    (Institute for Global Health UCL
    Royal Free London NHS Foundation Trust)

  • Sabine Kinloch

    (Royal Free London NHS Foundation Trust
    Royal Free Campus, UCL)

  • Tao Dong

    (University of Oxford)

  • Lucy Dorrell

    (University of Oxford)

  • Sarah Rowland-Jones

    (University of Oxford)

  • Laura E. McCoy

    (University College London)

  • Dimitra Peppa

    (University of Oxford
    University College London
    CNWL NHS Trust)

Abstract

There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH.

Suggested Citation

  • Aljawharah Alrubayyi & Ester Gea-Mallorquí & Emma Touizer & Dan Hameiri-Bowen & Jakub Kopycinski & Bethany Charlton & Natasha Fisher-Pearson & Luke Muir & Annachiara Rosa & Chloe Roustan & Christopher, 2021. "Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26137-7
    DOI: 10.1038/s41467-021-26137-7
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