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Brain adiponectin signaling controls peripheral insulin response in Drosophila

Author

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  • Nathalie Arquier

    (Aix-Marseille University, INSERM, TAGC, UMR_S1090)

  • Marianne Bjordal

    (Université Côte d’Azur, CNRS UMR7277, Inserm U1091, iBV, Parc Valrose)

  • Philippe Hammann

    (Plateforme Protéomique Strasbourg-Esplanade FRC 1589, University of Strasbourg, CNRS)

  • Lauriane Kuhn

    (Plateforme Protéomique Strasbourg-Esplanade FRC 1589, University of Strasbourg, CNRS)

  • Pierre Léopold

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934)

Abstract

The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. We further show that central AdipoR signaling inhibits peripheral Juvenile Hormone (JH) response, promoting insulin signaling. In conclusion, we identify a neuroendocrine axis whereby AdipoR-positive neurons control systemic insulin response.

Suggested Citation

  • Nathalie Arquier & Marianne Bjordal & Philippe Hammann & Lauriane Kuhn & Pierre Léopold, 2021. "Brain adiponectin signaling controls peripheral insulin response in Drosophila," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25940-6
    DOI: 10.1038/s41467-021-25940-6
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