IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25708-y.html
   My bibliography  Save this article

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Author

Listed:
  • Maximilian Y. Deng

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ))

  • Dominik Sturm

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ)
    Heidelberg University Hospital)

  • Elke Pfaff

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ)
    Heidelberg University Hospital)

  • Martin Sill

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Damian Stichel

    (Heidelberg University Hospital
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Gnana Prakash Balasubramanian

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Stephan Tippelt

    (Essen University Hospital)

  • Christof Kramm

    (University Medical Center Goettingen)

  • Andrew M. Donson

    (University of Colorado School of Medicine)

  • Adam L. Green

    (University of Colorado School of Medicine)

  • Chris Jones

    (The Institute of Cancer Research)

  • Jens Schittenhelm

    (Tübingen University Hospital)

  • Martin Ebinger

    (Children’s University Hospital)

  • Martin U. Schuhmann

    (Tübingen University Hospital)

  • Barbara C. Jones

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ)
    Heidelberg University Hospital)

  • Cornelis M. Tilburg

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Andrea Wittmann

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ))

  • Andrey Golanov

    (NN Burdenko Neurosurgical Institute)

  • Marina Ryzhova

    (NN Burdenko Neurosurgical Institute)

  • Jonas Ecker

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Till Milde

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Olaf Witt

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Felix Sahm

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • David Reuss

    (Heidelberg University Hospital
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • David Sumerauer

    (Motol University Hospital, Charles University)

  • Josef Zamecnik

    (Motol University Hospital, Charles University)

  • Andrey Korshunov

    (Heidelberg University Hospital
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Andreas Deimling

    (Heidelberg University Hospital
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • Stefan M. Pfister

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Heidelberg University Hospital
    German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK))

  • David T. W. Jones

    (Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
    Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ))

Abstract

Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.

Suggested Citation

  • Maximilian Y. Deng & Dominik Sturm & Elke Pfaff & Martin Sill & Damian Stichel & Gnana Prakash Balasubramanian & Stephan Tippelt & Christof Kramm & Andrew M. Donson & Adam L. Green & Chris Jones & Jen, 2021. "Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25708-y
    DOI: 10.1038/s41467-021-25708-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25708-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25708-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25708-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.