IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25497-4.html
   My bibliography  Save this article

Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

Author

Listed:
  • Kevin Wittwer

    (Paul-Ehrlich-Institute)

  • Danielle E. Anderson

    (Duke-NUS Medical School)

  • Kristin Pfeffermann

    (Paul-Ehrlich-Institute)

  • Robert M. Cox

    (Georgia State University)

  • Josef D. Wolf

    (Georgia State University)

  • Sabine Santibanez

    (Robert Koch-Institute)

  • Annette Mankertz

    (Robert Koch-Institute)

  • Roland Plesker

    (Paul-Ehrlich-Institute)

  • Zachary M. Sticher

    (Emory University)

  • Alexander A. Kolkykhalov

    (Emory University)

  • Michael G. Natchus

    (Emory University)

  • Christian K. Pfaller

    (Paul-Ehrlich-Institute)

  • Richard K. Plemper

    (Georgia State University)

  • Veronika von Messling

    (Paul-Ehrlich-Institute
    Federal Ministry of Education and Research)

Abstract

Measles virus (MeV) is a highly contagious pathogen that enters the human host via the respiratory route. Besides acute pathologies including fever, cough and the characteristic measles rash, the infection of lymphocytes leads to substantial immunosuppression that can exacerbate the outcome of infections with additional pathogens. Despite the availability of effective vaccine prophylaxis, measles outbreaks continue to occur worldwide. We demonstrate that prophylactic and post-exposure therapeutic treatment with an orally bioavailable small-molecule polymerase inhibitor, ERDRP-0519, prevents measles disease in squirrel monkeys (Saimiri sciureus). Treatment initiation at the onset of clinical signs reduced virus shedding, which may support outbreak control. Results show that this clinical candidate has the potential to alleviate clinical measles and augment measles virus eradication.

Suggested Citation

  • Kevin Wittwer & Danielle E. Anderson & Kristin Pfeffermann & Robert M. Cox & Josef D. Wolf & Sabine Santibanez & Annette Mankertz & Roland Plesker & Zachary M. Sticher & Alexander A. Kolkykhalov & Mic, 2021. "Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25497-4
    DOI: 10.1038/s41467-021-25497-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25497-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25497-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Robert M. Cox & Josef D. Wolf & Nicole A. Lieberman & Carolin M. Lieber & Hae-Ji Kang & Zachary M. Sticher & Jeong-Joong Yoon & Meghan K. Andrews & Mugunthan Govindarajan & Rebecca E. Krueger & Elizab, 2024. "Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25497-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.